摘要
本实验对大鼠中度烧冲复合伤后脾淋巴细胞增殖反应、白细胞介素—2的变化进行了观察,并对前列腺素E_1和消炎痛的调节作用进行了研究。结果发现,伤后脾淋巴细胞增殖反应除伤后第一天明显降低,3、5、7天均明显增加,14天恢复正常。IL—2诱生在伤后明显增加,14天恢复正常。PGE_1对淋巴细胞增殖反应和IL—2诱生均有显著或非常显著的抑制作用;而消炎痛却有不同程度的增强作用。上述结果表明,中度烧冲复合伤对大鼠细胞免疫功能有刺激作用;PGE_1可显著抑制细胞免疫功能,而消炎痛可显著增强烧冲复合伤后细胞免疫功能。
This experiment was taken to study the changes of cell mediated immunity (CMT) after burn—blast combined injuries in rats and the regulatory effects of indomethacin and PGE_1 on CMT. Mitogen stimulated blastogenic transformation (MSBT) and interleukin—2 (IL—2) were measured in 54 rats before injury and on 1, 3, 5, 7, 14 days after injury. The results showed that MSBT increased significantly on days 3. 5 and 7 but decreased significantly on day 1. IL—2 increased significantly after injury and did not return to normal until day 14. MSBT and IL—2 production were significantly depressed by PGE_1 but on the other hand much enhanced by indomethacin. PGE_1 and indomethacin had no effect on MSBT and IL—2 production in the control group. These results indicate: 1. moderate burn—blast combined injuries can stimulate CMI in rats: 2. PGE_1 can significantly depress IL—2 production and MSBT in rats after injury: 3. Indomethacin can enhance IL—2 production in rats after injury and 4. PGE_1 and indomethacin have no regulatory effect on IL—2 production and MSBT in normal rats.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1993年第5期274-276,共3页
Chinese Journal of Trauma
关键词
烧冲复合伤
细胞免疫
消炎痛
烧伤
Burn—blast combined injuries Cell mediated immunity Spleen lymphocyte mitogen stimulated blastogenic transformation Interleukin—2 PGE_1 Indomethacin
