摘要
对64例NIDDM、17例IDDM患者进行胰升糖素-C肽释放试验,结果显示注射胰升糖素后6分钟C肽值可反映胰岛B细胞储备功能。6分钟C肽值≥0.6nmol/L者,临床可用口服磺脲类降糖药治疗的符合率95％;<0.6nmol/L者,需用胰岛素治疗的符合率83％。提示该试验对糖尿病分型和指导治疗有较高的使用价值。
In order to evaluate B cell function in diabetics, fasting and glucagon-stimulated serum C-peptide were measured in 64 NIDDM and 17 IDDM. The result showed that with 6-min serum C-peptide level > 0.6 nmol/L after 1 mg glucagon intravenous injection, 95% of diabetic patients did not require insulin. Conversely, with C-peptide level <0.6 nmol/L, 83% of diabetic patients required insulin. The determination of 6-min C-peptide after glucagon stimulation gives a good investigation for direct assessment of endogenous insulin secretory reserve, and helps to make a decision in the management of patients with diabetes mellitus.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1993年第2期80-82,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
胰升糖素
糖尿病
C肽
胰岛
B细胞
Glucagon Diabetes mellitus C-peptide Islet B cell function
