摘要
用M-bcr 3′端同源DNA探针检测7例慢性粒细胞性白血病(CML,简称慢粒)患者急变前后bcr/abl融合基因的形成特征。发现其中3倒CML患者在临床急变后出现新的bcr/abl融合基因,提示部分CML急变可能与新的bcr/abl融合基因的形成有关。
The fusion pattrens of bcr/abl hybrid gene before and after the blastic crisis in 7 CML patients were analyzed systematically by Southern blot with DNA probe homologous to M-ber 3'end. A new bcr/abl hybrid gene was discovered at the crisis stage in 3 of the patients, suggesting that different patterns of bcr/abl hybrid gene might have participated in the heterogeneity before and after the crisis of CML genetically. 4 of the 7 cases we studied did not show this. The evolution of CML may be due to the synergism of many factors.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1993年第4期216-218,共3页
Chinese Journal of Medical Genetics
关键词
白血病
粒细胞性
分子遗传学
Leukemia, myelocytic, chronic bcr/abl hybrid gene
