摘要
综述了中药在调节细胞因子和免疫效应细胞活性方面的研究进展。大量临床观察和动物实验表明,中药可广泛调节白细胞介素(LK_s)、干扰素(IFN)等的生成和活性,可影响自然杀伤细胞(NK)等的细胞毒活性。在分子、细胞水平开展中药免疫调节机理的研究,有助于揭示中药对于机体整合的药理作用和与功能状态相关的调节效应。文章亦分析了中药免疫药理的量效关系,体内与体外研究的关系,中药与有效成分的关系。
The methods and technology of immunopharmacology for Chinese Materia Medica have been progressing rapidly in recent years. The regulation of Chinese Materia Medica on the activity of cytokine and effector cells is reviewed in this article. Many clinical studies indicate that Chinese Materia Medica can regulate the production and activity of IFN, ILs, TNF, etc., and affect the cytotoxieity of NK. LAK, CTL, etc. The immunopharmcological research of Chinese Materia Medica in molecular and cellular levels is useful for explaining the mechanism of whole regulation and two-way regulation depending on the function of the body. In this article, the relations between quantity and effect, the study in vivo and in vitro, and the whole drug and its component are also reviewed.
出处
《中药新药与临床药理》
CAS
CSCD
1993年第4期46-49,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
中草药
免疫学
免疫药理学
细胞因子
NK细胞
MEDICINAL HERBS/immunology KILLER CELLS, NATURAL/immunology INTERFERONS/immunology INTERLEUKIN_1/immunology INTERLEUKIN_2/immunology
