摘要
本试验应用从加拿大引种自发性糖尿病大鼠(简称BB Wistar大鼠)进行一年半的饲养繁殖试验。通过对该动物的生长发育、代谢观察及脏器重量等项指标的检测以及对影响其子代发病率的因素进行了讨论。结果证明:自发性糖尿病大鼠后代发病率较高(10％～39％),不同家系内和亲代不同交配方式影响子代发病率。此外,发病鼠的生长发育、机体代谢与人类青年型糖尿病十分相似。BB Wistar大鼠可作为一种自发性动物模型用于人类青年型糖尿病及其并发症的研究。
BB Wistar rats obtained from Health and Welfare, Canada, were observed on feeding, growth and development, metabolism, organ weight changes and reproduction. Assorted genetic mating resulted in different rates of occurrence of overt diabetes in the progeny. Body growth and metabolism in the diabetic rats resemble human juvenile diabetes greatly. Thus, BB 'Wistar rats might be valuable as an animal model in the study of human juvenile diabetes and its complication.
出处
《上海医科大学学报》
CSCD
1989年第1期40-44,共5页
Journal of Fudan University(Medical Science)
关键词
自发性糖尿病
生长发育
繁殖
大鼠
spontaneous diabetic BB Wistar rat
animal model
feed and reproduction
