摘要
在175例经肾穿刺明确诊断的成人原发性肾病综合征中,分析其病理类型及临床表现,实验室检查和疗效的关系。肾病综合征疗效和病理类型关系密切,微小病变性肾病和局灶增生性肾炎的缓解率分别达96.3％和83.3％,而局灶性肾小球硬化症和膜增生性肾炎则分别为21.4％和23.76％,膜性肾病为48.1％。肾病综合征伴血尿,尿纤维蛋白降解产物阳性和非选择性蛋白尿者,疗效显著地差,p<0.001。
The correlation between clinical manifestations, laboratory findings pathological type and therapeutic effect with corticoid immunosuppressant in 175 cases of idiopathio nephrotic syndrome (INS) was studied. The therapeutic effect had a close relation to pathological type of INS. Minimal change nephropathy (MGN) and focal paoliferative GN (FGN) responded best to therapy. Complete and partial remissions were induced in 96.3% and 83.3% of patients, respectively. The next in order were diffuse, mesangial proliferative GN(MsPGN), membranous nephropathy (MN) and IgA GN. The poorest response to therapy was focal segmental glomerulo-selerosis (FSGS) and membroproliferative GN (MPGN). the remission rates were 21.4% and 23.7%, respectively. Oases with hematuria, positive urine FDP and non-selective prote.inuria ha-d a poorer response to therapy than those without hematuria, with negativeunrine FDP and selective proteinuria.
出处
《上海医科大学学报》
CSCD
1989年第3期213-216,共4页
Journal of Fudan University(Medical Science)
关键词
肾病综合征
肾活组织检查
尿蛋白
nephrotic syndrome
renal biopsy
seleetivity of proteinuria
