摘要
用高、低剂量顺氯氨铂(DDP)联合化疗,配合手术,治疗32例晚期卵巢上皮性癌,近期疗效为81.5％(22/27)～85.7％(18/21),2年存活率71.9％(23/32)。27例有残余肿瘤,经9个疗程以上化疗后,其中8例无癌的证据。结果表明,该方案毒性反应轻,可反复应用,对延长肿瘤缓解期有一定作用,并在争取适宜的手术时机,创造尽量切除肿瘤的条件等方面,取得成效。
This report present a high intraperitoneal dose (80mg/m2) and a low intravenous dose (20mg/m5) cisplatinum (HD-DDP-IP and LD-DDP-Ⅳ) in various combination with other drugs (5-fluorouracil, oytoxan, mitomyoin, adrimyoin and AT1258) administered to 32 FIGO stage Ⅲ and Ⅳ patients with epithelial cancer of the ovary as adjunct to surgical treatment. The clinical trial was carried out between April 1984 and June 1986. The results of this study in terms of response rates, survival and toxioity were evaluated. The patients received 7-12 courses (mean, 9) of oisplatin. The response rate of 21 patients with secondary aeoites from the ovarian cancer on HD-DDP-IP and of 27 patients with residual disease on LD-DDP-IV were 85.1% (18/21) and 81.5%(22/29) repeotively. The 2-year overall survival rate was 71.9% (23/32) with mean survival duration of 32.5 months. Second-look operations were performed on 12 patients who had received 9 courses of chemotherapy and were without clinical eviflenoe of disease, 8 patients had no gross evidence disease at the second look operation, the remaining patients endured extended surgery with removal of the remaining reproductive organs. All of them achieved more them 2-year survival duratione. Toxioity in both regimens was mild and reversible after cessation of treatment, this proving greater opportunity for repeated courses of treatment and a better prognosis.
出处
《上海医科大学学报》
CSCD
1989年第5期378-381,共4页
Journal of Fudan University(Medical Science)
关键词
顺氯氨铂
肿瘤减灭术
卵巢癌
cisplatin chemotherapy
debulking operation
ovarian cancer
