摘要
本文报道了用微核试验方法对维生素Ａ拮抗氯化汞（ＨｇＣｌ２）致小鼠胸骨骨髓多染红细胞微核作用的研究．结果表明，给小鼠补充维生素Ａ１．０２ｍｇ／ｋｇ及以上剂量时，有明显地拮抗ＨｇＣｌ２的致微核作用（Ｐ＜０．００１）．在ＨｇＣｌ２染毒前１２０ｍｉｎ和染毒后６０ｍｉｎ内给小鼠补充维生素Ａ１．０２ｍｇ／ｋｇ时，同样具有显著地降低其致微核作用（Ｐ＜０．０５～Ｐ＜０．００１）．一个月的试验结果表明，隔日给小鼠补充低剂量的维生素Ａ０．５ｌｍｇ／ｋｇ，也可产生显著地拮杭ＨｇＣｌ２１．０ｍｇ／ｋｇ的致微核作用．
In this paper,antagonistic effects of vitamin A(VA) on the rate of micronuclei in themice bone marrow polychromatic erythrocyte induced by mercuric chloride(HgCl2)was reported.The micronucleus test method was used.It showed that the rate of micronuclei induced by thecombining VA 2.04,1.02 mg/kg body weight plus HgCl2 1.0mg/kg body weight respectively wasmuch lower than that of HgCl2 1.0mg/kg control group(P<0.001).When the mice received VA1.02mg/kg within l20 min before and 60 min after with HgCl2 1.0mg/kg,the rate of micronucleiwas much lower than that of HgCl2 1.0mg/kg control group(P<0.05 rang P<0,00l).When themice received treatment with VA 0.51mg/kg every two days for a month,the antagonistic effectof micronuclei caused by HgCl2 l.0mg/kg was also obvious.
出处
《蚌埠医学院学报》
CAS
1994年第2期101-104,共4页
Journal of Bengbu Medical College
关键词
维生素A
氯化汞
微核试验
vitamin A(VA)
mercuric chloride(HgCl2)
micronucleus test
mice
