摘要
人胎肝刺激因子具有明显的保肝作用。本文采用Ｄ－半乳糖胺及ＣＣｌ４损伤小鼠肝脏，进一步观察人胎肝刺激因子（ｈＨＳＳ）对肝损伤引起的微粒体Ｃａ２＋－ＡＴＰ酶和混和功能氧化酶（Ｐ４５０）活性的保护作用，结果发现，肝损伤后，两种酶活性均明显降低，而预先经ｈＨＳＳ处理后，上述两种酶活性均有不同程度的恢复或增加。结果表明，ｈＨＳＳ的保肝作用，可能与保护肝细胞的钙稳定及加强肝细胞代谢酶活性有关。
We have demonstrated that human hepatic stimulator substance (hHSS) has hepatic protection. This experiment is to observe further effect of hHSS on the functional change of liver mixed function oxidase and Ca2+-ATPase activity after administrated with hepatotoxin (D-galactosamine and CCl4). The result showed that D-galactosamine and CCl4 can markedly decrease the activity of liver microsomal mixed functiooxidase and Ca2+-ATP ase, while the rate were pretreated with hHSS 6h before the hepatotoxin given, the activity of both above enzymes could be prevented in different extent. This study suggested that the protective effect of hHSS on liver might be related to maintaining liver calcium homeostasis and enhancing metabolism of biological oxidation of liver cells.
基金
1992年度辽宁省科委资助
关键词
人
胎肝刺激因子
肝
保护
生理
human hepatic stimulator substance(hHSS)
hepatic protection
D-galactosamine
CCl_4 , Ca￣(2 +)-ATPase
P450
