摘要
根据高原缺氧作用特点配制高原Ⅱ（ＫＹ－Ⅱ）号药（中西复方），在动物实验证明具有降低缺氧动物的氧耗量、延长活存时间和提高活存率的基础上，选用１８～２５岁健康男性青年２３名，随机分为高原Ⅰ号（ＫＹ－Ⅰ，安慰剂，ｎ＝１２）和ＫＹ－Ⅱ号药组，减压至模拟４０００～５０００ｍ高原低氧环境连续生活７２ｈ，采用双盲法，观察ＫＹ－Ⅱ号药预防急性高原反应的效果。结果表明：ＫＹ－Ⅱ号药组急性高原反应发病人数少于ＫＹ－Ⅰ号组；按照Ｊｏｈｎｓｏｎ等计分法进行症状量化分析，在模拟５０００ｍ高原时．ＫＹ－Ⅱ号药组的得分显著低于ＫＹ－Ⅰ号组（Ｐ＜０．０５），重度急性高原反应人数少于ＫＹ－Ⅰ号组（Ｐ＜０．０５）；症状反应的轻重与动脉血氧饱和度（ＳａＯ２）呈显著负相关（ｒ＝－０．９９８，Ｐ＜０．０５）；两组间心缩间期（ＳＴＩ）各参数变化，在统计学上无显著意义（Ｐ＞０．０５）。上述结果表明，ＫＹ－Ⅱ号药具有减轻急性高原反应症状，降低其发病率的效果。
Twenty-three young adults with an age range of 18～25 were randomized into 2 groups.Group I of 12 individuals served as the control and received KY-Ⅰ(actually a placebo)and Group Ⅱ of 11 received KY-Ⅱ which is a composite of Chinese herb drugs and certain western medicine and has been proved to be effective to reduce oxygen consumption, prolong the average surviving duration and increase the survival rate of the hypoxic mice. Both the groups were subjected to continuous hypoxia in a hypobaric chamber and its barometric pressure was kept at a level equivalent to 4 000 m altitude for 48 hours and subsequently to 5000 m for 24 hours. Double blind method was used in observntions, Symptoms and signs of “acute mountain sickness”(AMS) were recorded. It was found that the suffers of AMS were fewer in Group Ⅱ than inGroup Ⅰ.The scores of symptoms and signs at the simulated altitudes of 4 000 m and 5 000 m were smaller in Group Ⅱ than in Group Ⅰ.The severity of AMS correlated with artetial oxygen saturation( r=-0.998,P<0.05)0 in both the groups. No significant difference of systolic time interval was observed between the 2 groups, These findings suggest that KY-Ⅱ is effective to reduce the morbidity and manifestations of AMS.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1994年第1期38-40,共3页
Journal of Third Military Medical University
