摘要
用低Ｃａ２＋高Ｍｇ２＋人工脑脊液灌流大鼠下丘脑脑片，观察在去甲肾上腺素（ＮＥ）作用下，背内侧核神经元的放电及介导ＮＥ作用的受体。实验结果表明ＮＥ主要对ＤＭＮ产生直接的抑制作用，并能被育亨宾阻断，而哌唑嗪及心得安的阻断作用则很小，提示ＮＥ的作用主要由突触后的α２受体介导。
By
perfusing the hypothalamic slices of rat with low calcium and high magnesium artificial
cere-brospinal fluid,we observed the discharge of impulses from neurons of the dorsomedial
nucleus(DMN) ef-fected by norepinephrine(NE),and the receptor mediating the effect of NE.The
results revealed that theeffect of NE on DMN was primarily an inhibition,which could be blocked
by yohimbine.The blockade ofprazosin and propranolol was weak.It suggested that the effect of
NE was mediated by the postsynapticreceptor.
出处
《第一军医大学学报》
CSCD
1994年第2期124-125,共2页
Journal of First Military Medical University
关键词
下丘脑
背内侧核
去甲肾上腺素
hypothalamic dorsomedial
nucleus
brain slice
norepinephrine
antagonist of adrenergic receptor
