摘要
本文报道苯酚类螯合剂８１０２和７６０１对大鼠中毒硝酸铀酰（１００－５００ｍｇ／ｋｇ）的解救效果和对肾脏损害的保护作用。实验观察到对照组大鼠腹腔注射硝酸铀酰５０ｍｇ／ｋｇ时，动物于３－４ｄ内全部死亡，并有明显的急性肾小管坏死和蛋白管型出现。８１０２和７６０１给药组对中毒硝酸铀酰１００－３５０ｍｇ／ｋｇ时都有明显的解救效果（ｐ＜０．０１）和肾脏损伤的病理改善；在中毒铀酰量１００ｍｇ／ｋｇ时，２１ｄ观察中仅有１０％的动物死亡，未见肾脏的病理变化。８１０２的作用效果优于７６０１。
In this paper,the effect of phenolic chelating agents,8102 and 7601,as antidotesfor acute uranyl nitrate (100-500 mg/kg)intoxication was examined.The results show thatafter intraperitoneal injection of 50 mg of uranyl nitrate per kg,all the control rats died at 3rdand 4rd days and exhibited acute renal tubular necrosis and protein casts. 8102 and 7601could promote the animals survival and reduce the histologic lesion of kidneys in rats intoxi-cated with uranyl nitrate(100-350 mg/kg).8102 is more effective than 7601.
出处
《辐射防护》
CAS
CSCD
北大核心
1994年第4期296-300,共5页
Radiation Protection
关键词
螯合剂
铀
解毒药
硝酸铀酰
肾
Chelating Agent,8102,Uranium,Antidote,Acute Renal Tubular Necrosis
