摘要
人外周血淋巴细胞在离体培养后６ｈ时，预先受到小剂量１、２、５、１０或２０ｃＧｙ６０Ｃｏγ射线单次照射，能降低随后１００ｃＧｙ照射所引起的染色单体畸变，而０．５或３０ｃＧｙ则不明显。１．０ｃＧｙ诱导的适应性反应最明显，是诱导适应性反应的最适剂量（饱和剂量）。淋巴细胞分别在培养后６ｈ和１２ｈ、６ｈ和４２ｈ或３６ｈ和４２ｈ时，预先受到０．５ＣＧｙ６０Ｃｏγ射线两次照射，均能显著降低在培养后４８ｈ受到大剂量１５０ｃＧｙ６０Ｃｏγ射线照射所诱发的染色单体畸变，且０．５ｃＧｙ两次与１．０ｃＧｙ单次照射所产生的作用相似，这显示０．５ＣＧｙ两次照射能引起累加作用，而且在培养后３６ｈ和４２ｈ０．５ｃＧｙ照射两次出现超常适应性反应。在上述时间内１．０ｃＧｙγ射线两次照射，其结果与１．０ｃＧｙ单次照射的结果几乎相同，这进一步表明１．０ｃＧｙ已达适应性反应的饱和剂量。
A chromosomal adaptive response to 60Co γ--rays in human lymphocytes was observed with pretreated doses ranged from 1 .0 to 20 cGy, with 1 .0 cGygave optimal reduction in chromatid breaks. A 0.5 cGy dose which in itself didnot induce an adaptive response, did so when given twice within the same cell cycle, and the-.magnitude of accumulative effect is the strongest when there was an interval of .6 h between the two adaptive doses and between the second adaptive doseand a challenge dose. Reductions equiyalent in effect to a single 1 .0 cGy dose were seen when a 0.5 cGy dose was given twice. Delivering two 1 .0 cGy doses had nogreater effect than did a single dose of 1 .0 cGy.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1994年第1期34-39,共6页
Journal of Radiation Research and Radiation Processing
关键词
适应性反应
淋巴细胞
Γ辐射
Adaptive response, Chromatid breaks, Adaptive dose(s). Human lymphocytes, γ-radiation
