摘要
青光眼是致盲的主要疾病之一。其损害除视神经、晶状体、虹膜外,眼压增高还可导致角膜内皮细胞功能障碍。如急性闭角青光眼发作可有角膜实质层水肿,后弹力层皱褶及角膜内皮水肿、临床应用角膜内皮显微镜,可对活体角膜内皮的变化进行观察,为认识角膜水肿产生的病理生理机制及预后估计等提供了可靠的证据。本临床研究的目的在于观察青光眼急性发作时其眼压持续时间以及高、低眼压水平对角膜内皮细胞密度的影响,同时也观察了抗青光眼手术后内皮细胞密度的变化。 对象和方法 本组观察23例27眼急性闭角青光眼患者。男性7例9眼,女性16例18眼。年龄35～78岁,平均59.6岁。单眼发病19例,有4例在住院期间对侧眼发病,所有病人均为首次发作,经临床检查符合急性闭角青光眼诊断标准。伴有累及角膜的眼病均不属本组观察范围。 病人中均有眼痛、视朦、恶心呕吐。眼压高持续3天以上共12眼,3天以内(含3天)15眼,我们将眼压在6.25kPa以下为低眼压组。
The corneal erdothelium in 23 patients (27 eyes) with acute angle-closure glaucoma was examined and photographed by a Nikon non-contact specular microscope. We found that the average descending rate of corneal endothelium was 10.5% in attack eyes. There was very significant difference between attack and control eyes (P<0.001). The study showed that the higher IOP or the longer persistent period of attack2, the more damage of cro-neal endothelium of glaucoma. The authors observed the changes of corneal endothelium post-trabeculectomy and discussed the experience with treatment.
出处
《广东医学》
CAS
CSCD
1994年第1期4-5,共2页
Guangdong Medical Journal
