摘要
测定５０例正常人和１２５例不同心功能心脏病患者红细胞ＳＯＤ、血浆ＬＰＯ及全血ＧＳＨ－ＰＸ，并计算ＧＳＨ－ＰＸ／ＬＰＯ比值。结果表明：Ｉ～Ⅳ级心功能患者ＳＯＤ活性及ＧＳＨ－ＰＸ／ＬＰＯ比值均明显低于正常对照组（Ｐ＜０．００１），但与心功能分级无明显相关关系，ＧＳＨ－ＰＸ在不同心功能组间变化也无规律性，提示ＳＯＤ活性变化只是心脏病损的表现之一，与心衰程度关系不大，ＬＰＯ可作为心脏病损和心衰程度重要指标之一。在分析脂质过氧化程度时，ＧＳＨ－ＰＸ／ＬＰＯ比值较单用ＧＳＨ－ＰＸ敏感，但ＧＳＨ－ＰＸ／ＬＰＯ比值是否较单用ＬＰＯ敏感还有待更多的研究来证实。
Red blood cell SOD,plasma LPO,blood GSH-PX were measured andGSH-PX/LPO calculated in fifty normal persons and 125 patients with different grades ofheart failure The results showed that SOD activity and GSH-PX/LPO in patients with I～Ⅳ grades heart function were significtintly lower than the nomal group,but such decrement didnot correlate signiflcantly with the different grades of heart function, Also, there was regularityin the changes of GSH-PX among the different grades of heart function,Our results indicatedthat the changes of SOD activity were only an expression of heart leisons, and were not relatedto the degree of heart failure.LPO could be one of the important indicators in determining heartleisons and the degree of heart failure,In analyzing the degree of lipid poroxidation,GSH-PX/LPO is a more sensitire index than GSH-PX,but more data ase needed to confirmthat GSH-PX/LPO is a more sensitive index than LPO.
出处
《广西医科大学学报》
CAS
1994年第4期368-371,共4页
Journal of Guangxi Medical University
基金
国家自然科学基金
