摘要
从药动学-药效学结合模型的角度出发,通过几种血管紧张素转化酶抑制剂在临床治疗学及临床药效学上的应用,概述了血管紧张素转化酶抑制剂的药动学与药效学关系,尤其是血浆ACEI浓度、血管紧张素Ⅱ浓度、血管紧张素转化酶抑制作用及血压四者之间的相互关系.
The interrelationships between the pharmaeokinetic and pharmacodynamic behaviour ofACE inhibitors are reviewed. A pharmacokinetic-dynamic model is descrived which seems to be usefulfor the interpretation of the complex biochemical processes. The various correlations between plasmadrug concentration on the one hand and plasma ACE activity,angiotensin II Concentration in plasma orblood pressure on the other hand, are discussed on the basis of this model.
关键词
血管紧张素
转化酶抑制剂
药代动力学
药理
<Keyword>Angiotensin converting enzyme inhibitors
Pharmacokinetics
Pharmacodynamics
Combined pharmacokinctic and pharmacodynamic model
