摘要
本文对１５２例具有同胞患肝癌家族史的原发性肝癌先证者进行分析，结果表明：该组人群ＨＢＶ感染率为８１．５８％，感染标记类型有１２种，其中６８％为抗一ＨＢｃ阳性伴ＨＢｓＡｇ和（或）抗－ＨＢｅ阳性；发病高峰年龄为３０～４９岁（占７２％）；兄弟同患肝癌（６７．１１％）显著多于兄妹、姐弟同患，更显著多于姐妹同患（Ｐ＜０．００１），但伴有母患肝癌家族史的患者女性同胞也易患肝癌（Ｐ＜０．０２５）。提示具有同胞患肝癌史、年龄３０～４９岁、尤其是抗－ＨＢｃ阳性伴ＨＢｓＡｇ和（或）抗－ＨＢｅ阳性的男性乙肝患者为肝癌患者一级亲属中原发性肝癌最易感人群，应密切关注，警惕肝癌发生。
One hundred and fifty two patients with primary hepatocellular carcinoma(PHC) whose brothers died of PHC are analyzed in this report. The results show that HBV infection rate in this group is 81. 58%. There are 12 kinds of HBV marker type,of which 68% is anti-HBc positive with HBsAg and/or anti-HBe positive. The onset of PHC is at the age of 30-49(72% ).PHC occurs more often within brothers than within brother and sister,and obviously much more often than within sisters (P<0.001).But female patients whose mothers died of PHC are apt to have PHC (P<0. 025). It suggests that male patients with hepatitis B having brothers who died of PHC at the age of 30-49,especally those who have anti-HBc positive with HBsAg and/or anti-HBe positive and are the highest risk population in direct relation.with PHC patients more attention should be paid to them.
出处
《河南肿瘤学杂志》
1994年第1期14-16,共3页
Henan Journal of Oncology
