摘要
作者把乳突模型、链式模型、生理模型、静脉推注、输注及口服等血管外给药的各种线性药物动力学模型统一成一个数学模型，并给出了该模型的解法和药时关系的一般表达式。该模型对生理和非生理的任何室数、任何给药途径和消除途径的单剂、多剂的线性药物动力学过程都适用，从而进一步完善了线性药物动力学的理论和应用。
This paper reports the integration of pharmacokinetic models of mammilla,chain,physiology , in-travenous injection,intravenous infusion and extravascular administration into a single mathematical model.Wehave given a general mathematical treatment of this model and a common expression of drug concentration-time re-lationship.The model fits in any single or multiple dosing linear pharmacokinetic process involving in physiology,nonphysiology,and any compartmental adminstration and excretion。
出处
《华西医科大学学报》
CSCD
1994年第3期305-311,共7页
Journal of West China University of Medical Sciences
关键词
药物动力学
线性模型
室分析
Pharmacokinetics Linear model Compartmental analysis Physiological pharma-cokinetic models
