摘要
作者通过静脉给药探测￣３Ｈ－天麻甙元和￣３Ｈ－天麻素在小鼠体内的分布，并采用硅胶薄板层析法对注射￣３Ｈ－天麻素的小鼠组织提取液的放射性成份进行分析，研究了二者在小鼠体内的分布和代谢过程。结果显示：天麻素（Ｇａｓｔｒｏｄｉｎ）可以透过血脑屏障进入脑内，并在脑、血及肝中迅速分解为天麻甙元（Ｇａｓｔｒｏｄｉｇｅｎｉｎ），然后以天麻甙元的形式存留在脑组织内，发挥中枢镇静作用。天麻甙元和天麻素都主要经肾脏排泄，天麻素在小鼠体内可能存在肠肝循环。
The biodistribution and metabolismof￣3H-gastrodigenin and ￣3H-gastrodin after intra-venous injection were studied by the detection of theirradioactivity in mice tissue; the radioactive elements ofmice tissue extracts after intravenous injection of ￣3H-gastrodin were analyzed with thin-layer chromatogra-nhy(TLC).The results demonstrated that gastrodincould penetrate through the blood-brain barrier intothe brain,and it was rapidly decomposed into the gas-trodigenin in brain, liver and blood. Then gastrodi-genin preserved in brain and mediated its pharmacolog-ical inhibitive effects on the central nervous system.Most of the gastrodigenin and gastrodin were excretedby the kidney. The findings also suggested that gas-trodin might exist in the enterohepatic circulation.
出处
《华西医科大学学报》
CSCD
1994年第3期325-328,共4页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
关键词
天麻素
天麻甙元
药代动力学
Gastrodigenin Gastrodin Biodistribution and metabolism Enterohepatic circulationThe Project Supported by National Natural Science Foundation of China
