摘要
作者用手术证实的２０～４４岁已婚女性为胆囊结石病人为病例组，与同期入院的非结石病人按，年龄、性别、入院日期进行１：１配对。共对８３０对病人进行了病例对照研究以探讨甾体避孕药与胆囊结石的关系。研究中尽可能排除了影响内源性或外源性雌激素水平的因素。单因素及多因素Ｌｏｇｉｓｔｉｃ回归分析结果显示，居住地、受教育水平、职业、家庭收入、妊娠、分娩史、体重指数及脂肪摄入量等在本研究条件下均非胆囊结石形成的危险因素，而甾体避孕药使用史及热量摄入是影响胆囊结石形成的主要危险因素。本研究尚提示多数结石在使用甾体避孕药３年后形成，但与药物剂量无关。
The author adopted the surgically-confirmed gallstone patients as a case group, in pairing with which non-gallstones subjects hospitalized at the same period formed a control group.A case-control study was made on 830 pairs of cases to explore the relationship between steroid hormone contraceptives and gallstone formation. The influence of endogenous and exogenous oestrogen concentration change except that of contraceptives was excluded in our study as clearly as possible. All the data showed through multiple regression analysis that under the condition of our study, none of home location, education level, occupation, family income. preguancy, delivery history and relative weight etc,were risk factors for stone formation, but high caloricintaking and the use of steroid contraceptives were really the main risk factors. These data also suggested that stone formation was not correlated with the dosage of contraceptives, and that it usually took 4 years or more from the first contraceptive use to the formation of stone.
出处
《华西医学》
CAS
北大核心
1994年第3期289-293,共5页
West China Medical Journal
基金
世界卫生组织资助
关键词
甾体避孕药
病例对照研究
胆结石
Steroid hormone contraceptives
Gallstone
Case-control study
