摘要
采用同步辐射荧光分析光谱法（ＳＲＸＦＳ）对９例直肠癌及癌旁移行粘膜和正常粘膜中微量元素的含量进行分析，结果显示，癌组织中Ｃｕ、Ｚｎ、Ｍｎ三种微量元素相对含量分别为３８１９９．１６、１５５５７．０４和２０９．８６，显著低于正常粘膜组织（Ｐ＜０．０５，或Ｐ＜０．００１）；而宏量元素Ｃｌ含量为３４３８．１６，显著高于正常粘膜（Ｐ＜０．０５）。癌旁移行粘膜中Ｃｕ、Ｚｎ、Ｍｎ、Ｃｌ、Ｔｉ、Ｓｅ元素含量介于癌组织和正常粘膜之间，作者认为，微量元素Ｃｕ、Ｚｎ、Ｍｎ可能是直肠癌的相关性元素，癌旁移行粘膜多种元素含量变化趋势，提示癌旁移行粘膜可能是一类潜在性交界性瘤变。
Synchrotron radiation is a high intensive and collimate X-ray source and is high linearly polarized in theelectron orbital plane,SRXFS analysis has the advantages of high sensitivity and minimum background fromscattering photoes. Nine cases of human rectal cancer tissue;transitional mucosa adjacent to cancer and nor-mal mucosa were analysed with SkXFS at National Laboratory of synchrotron radiation in Beijing,The re-sults showed that relative counts of trace elements copper(Cu),zinc(Zn)and mangauese(Mn)of the cancertissues were 38119.16,15557.04 and 209.86,respectively,which were significantly lower than normal mucosa(P<0.05,P<0.01).Those of major element chlorine(Cl)in cancer tissue were 3438.16 which were signif-icantly higher than normal mucosa(P<0.05).The relative counts of Cu,Zn,Mn,Cl,Ti and Se of transitionalmucosa were intermediate between cancerous tissue and normal mucosa. The results suggested that trace ele-ments Cu ,Zn ,Mn may be associated with rectal cancer in which the counts of Cu,Zn,Mn were decreased,andtransitional mucosa may be a potential borderline lesion between rectal carcinoma and normal epithelium.
出处
《科技通报》
1994年第1期1-5,共5页
Bulletin of Science and Technology
基金
国家"八五"攻关课题
关键词
直肠肿瘤
同步辐射
微量元素
癌
synchrotron radiation
rectum
intestinal carcinoma
trace element
