摘要
研究了丹参对高脂喂饲大鼠的血清脂质水平、肝低来度脂蛋白（ＬＤＬ）受体ｍＲＮＡ和载脂蛋白（ａｐｏ）Ａ－ＩｍＲＮＡ水平的影响，以及对培养的人成纤维细胞上述两种ｍＲＮＡ水平的影响。发现丹参能升高鼠肝及人成纤维细胞ＬＤＬ受体ｍＲＮＡ水平，但降血清总胆固醇及ＬＤＬ胆固醇作用不明显。提示ＬＤＬ受体可能存在翻译或翻译后水平的调节。丹参对鼠肝及人成纤维细胞ａｐｏＡ－１ｍＲＮＡ水平未见有影响。
Effects of Chinese medicine,Salvia Miltiorrhiza on serum lipid levels,hepatic low density lipoprotein (LDL) receptor and apolipoprotein(apo) A-I mRNA levels were studied in cholesterol-loaded rats and cultured human fibroblasts. It was observed that Salvia Miltiorrhiza enhanced LDL recceptor mRNA levels in rat liver and in cultured human fibroblasts,but acted less effectively in lowering serum total cholesterol and LDL-cholesterol,suggesting translational or post-translational regulation of LDL receptor. No effects on apoA-1 mRNA levels of rat liver and human fibroblasts were noticed.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1994年第4期522-525,共4页
Journal of Nanjing Medical University(Natural Sciences)
关键词
丹参
高胆固醇血症
载脂蛋白
基因表达
大鼠
salvia miltiorrhiza
hypercholesterolemia,LDL receptor
apolipoprotein A1
gene expression
rat
