摘要
为研究大肠癌的发生机制，作者对１５只正常雄性Ｗｉｓｔａｒ大白鼠用二甲基肼（ＤＭＨ）每周皮下注射，连续１５周，进行诱癌实验，并用５只同样的Ｗｉｓｔａｒ鼠接受生理盐水注射作为对照。以ＰｅｎｔａｘＣＨＦ－４Ｂ型人类胆道镜作大鼠的肠镜检查。１５周内共完成１１６内次肠镜检查，其中全结肠镜检查为１１１只次，达盲肠的成功率为９３％。结果说明，通过全结肠镜检查研究大鼠结肠癌的发生和发展是易行和可信的。
In order to study the carcinogenestic mechanism of chemicals on large bowel,15 male wistar rats were injected with 1,2-dimethylhydrazine(DMH) for 15 weeks once a week ,and 5 similar rats were received injection of saline as contral group. Animals in both groups were observed through colonoscopy with pentax CHF-4B type human cholodochoscope as rat endoscope.During 15 weeks a total of 116 colonoscopies was performed,endoscope was inserted into cecum in 111 times.The successful rate of pan-colonoscopy was 93%.The results Showed that pan-colonoscopy was easy and reliable to observe the genesis and development of large bowel cancer in rats.
出处
《内镜》
1994年第4期204-205,共2页
关键词
大白鼠
结肠肿瘤
结肠镜检
Rats Coloractal Carcinoma Colonoscopy
