摘要
本文采用紫外分光光度法，研究了经口灌服和静脉注射盐酸吗啉胍后，在成年健康尼克蛋鸡体内的药物代谢动力学过程．主要药物代谢动力学参数：消除半衰期为９．９８±１．０４ｈ－１与８．５２±０．３６ｈ－１．分布半衰期为１．５６±０．７１ｈ－１与０．４９±０．０９ｈ－１，总消除速率常数为４．４０６３±０．２７２ｍｇ／ｋｇ．ｈ与５．５５７９±１．２６３ｍｇ／ｋｇ．ｈ，总表观分布容积为６５５．９９±８７９．７２ｍｌ／ｋｇ与５４６９．３±２５５．８ｍｌ／ｋｇ，中央室消除速率常数为０．０７５±０．０１８ｈ－１与０．１２９±０．０２９９ｈ－１，药时曲线下面积为１１．２５±１．５６ｍｇ／Ｌ．ｈ与２２．８１±０．５ｍｇ／Ｌ．
This paper deals with the pharmacokinetics process of drug metabolism by using ultraviolet spectroscope method in adult Nike chickens injected or fed with Moroxydini Hydrochloridum. The main pharmacokinetics parameters are as follows: eliminated half-life:9.98±1.04h-1and8.52±0.36h-1,distributive half- life:1.56±0.71h-1and 0.49±0.09h-1,total eliminated rate constant:4.4063±0.272mg/kg.h and 5.5579±1.263mg/kg' h, total appearanced volume: 6355.99±879.72ml/kg and 5469.3±255.8ml/kg,central eliminated rate constant:0.075 ±0.018h-1 and 0.129±0.0299h-1,areas under curve of drug:11.25±1.56 mg/L.h and 22.81±0.5mg/L'h.
出处
《沈阳农业大学学报》
CAS
CSCD
1994年第4期422-426,共5页
Journal of Shenyang Agricultural University
基金
辽宁省教委研究课题
关键词
盐酸吗啉胍
药物代谢动力学
参数
卵用鸡
moroxydini hydrochloridum,Nike chicken,pharmacokinetics parameter
