摘要
用先进的图像分析系统，观察了中药大黄提取物Ⅰ号对链脲菌素（ＳＴＺ）所致糖尿病肾病大鼠模型肾小球形态学的影响，结果提示，在病程第三天糖尿病组大鼠肾小球干均体积较大黄提取物Ⅰ号治疗组大鼠明显增大（Ｐ＜０．０１）；病程的第三、七和第１４天糖尿病组大鼠肾小球系膜区平均面积较治疗组扩大，有统计学差异（分别为Ｐ＜０．０１．Ｐ＜０．０１和Ｐ＜０．００１）．本研究在实验性大鼠的体内进一步证实大黄提取物Ⅰ号抑制肾脏肥大的作用。
he effect of Rhubarb on the glomerulichanges in the
streptozotocin-induced dia-betic drats were analysed by moyphometricsystem IA-1. These data
suggested the'nean volurne of glorneruli in diabetic rats ishigher than rats treated by Rhubarb
duringthe course of the disease at day 3 (P<0. o1). The area of mesangial matrix was al-so
greater in diabetic rats than in Rhubarbtreated rats at day of 3,7 and 14, and therewas a
statistically significant difference be-tween diabetic rats and Rhubarb treatedrats trespectively
P<0.01, P<0. 01 and P< 0. 01). Our study confirmed the Rhubarbmay inhibit renal hypertrophy
in experimen-tal diabetic rats.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1994年第6期455-458,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
