摘要
本文作者把烧伤病人计算机仿真应用于临床烧伤病人。为此,首先按照不同病人的体重,平均动脉压,血浆蛋白浓度等的差异,根据人体内毛细血管壁上液体和蛋白交换的平衡条件,确定每个病人微循环交换的稳态工作点。并且通过实测烧伤病人最初2天内的血球压积数值的变化态势,可以估计出烧伤对毛细血管壁交换影响程度的一个参数A_(pll)。然后对烧伤病人在整个休克期的2-3天内情况进行了计算机仿真。通过对四例大面积烧伤病人的血浆蛋白浓度,净体重变化的实测值与计算值的比较,数学模型及仿真的有效性获得了验证。同时,它向临床提供了循环血浆容量变化,水肿等很有价值生理量的动态变化过程。
In the burn patient simulator we set up and determined a set of the operating point of stable state of microcirculation exchange for the burn patient individual according to the balance condition of exchange of the fluid and protein accross the capillary wall?taking the differences of the body weight. mean arterial pressue and concentration of plasma protein in the individuals into account. The mentioned operating point is necessary for carrying out computer simulation in the burn patient individual. We estimate the parameter Apll referring to the change in the transfer coefficient of capillary wall by measuring the value of patient's hematocrit during the shock phase of the burn patient. Based on the determined parameter Apll. the computer simulations of the clinical burn patients were carried out. The effectiveness of the mathematical model was basically validated by comparing the measured values and theoretically calculated values of the change in net body weight and plasma protein concetration. Meanwhile, the dynamic changes of some physiological quantities including plasma volume and oedema during the patient shock phase r which are clinically useful. were given by computer simulation.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
1994年第4期323-329,共7页
Journal of Biomedical Engineering
基金
91年国家卫生部的资助
关键词
数字仿真
烧伤
临床验证
Burn patient Digital simulation Clinical validation
