摘要
本文以骨氟和牙氟含量为基础,对日服15.0～60.0mgNaF/kg100天的家兔的骨骼、骨骼肌、心肌、脑、肝脏、肾脏、睾丸或卵巢进行了组织学和超微结构的观察。研究发现,动物的骨氟和牙氟含量都已明显高于对照组(P<0.01),而骨组织形态和构造均未出现病变;但心肌、骨骼肌组织学检查已呈退行性变化,超微结构以膜和线粒体变化为主,同时伴有肌原纤维(或肌微丝)的断裂、崩解或部分消失。肝、肾未见明显结构性损伤。生殖器官无变化。 实验证明,给药组家兔骨、牙组织未见变化前,软组织(尤其是心肌和骨骼肌)已有代谢变化和结构损伤,且相当明显,故认为其变化系因NaF直接作用的结果,而非骨变形后所继发。
The investigation based on F concentration of incisor and ossacuboideum, using histological and cytological techniques, was carried out to observe structural changes in the bone and soft tissues (cardiac and skeletal muscles,cerebrum, ren,hepar and testicle or ovary)of 40 rabbits subjected for 100 days to sodium fluoride of 0 mg (group A) ,15mg(group B) ,30mg (group C) and 60 mg (group D) per kg body weight per day respectively. The results show that F level of incisor and ossacuboideum of dosed animals is obviously higher than that of controled ones(group A),whereas,no osseous structure change or damage can be discovered. In contrast,the cardiac and skeletal muscles are partly degenerated histologically. Particularly, the ultrastructural injuries make a signalizing picture of involved unit mamb-rans and mitochondria, which is companied with the erosion, mergence or partly disappearance of microfibres. Nevertheless, visible structural change is not discovered in liver, kidney and other soft tissues.
There seems to be some new data in current experimental study that the dosed animals have obvious structural injuries caused by the direct effects of sodium fluoride in soft tissues before osteofluorotic bone and dens emerge.
出处
《地方病通报》
1989年第3期5-9,85,共5页
Endemic Diseases Bulletin
关键词
氟化钠
骨氟
软组织
NaF—rabbits—bone, F level—soft tissue
