摘要
为了寻找和开发抗癌药的半合成原料鬼臼毒素,我们对川产八角莲的化学成分进行了研究。从川八角莲[Dysosma veitchii(Hemsl et wils)Fu.]的根茎中分离得到一种单体成分,经薄层对照,熔点,UV,IR,MS和H’—NMR测定,证明为鬼臼毒素(Podophyllo-toxin)。同时,作者采用薄层层析—紫外分光光度法,对川八角莲和小八角莲[D.difformis(Hernsl et wils)T.H·wang ]中的鬼臼毒素进行了含量测定,分别为0.057％和0.15％。为进一步开发利用鬼臼类植物提供了科学依据。
In order to search the plant sources for the potential antitumor agents,we have studied the chemical constituents from Dysosma plants in Sichuan.Podophyllotoxin.which has been used as a raw materical of synthetic antitumor agents,was isolated from the rhizome of Dysosma veitchii(Hemsl et wils.)Fu.Its structure was identified by interpretation of its spectral data(UV,IR,MS and H' NMR)and MP.At the same time,the content of Podophyllotoxin in D,veitchii and D.difformis were deter-minded by TLC-UV spectrophotometry.They were 0.057% and 0.15%,respectively.Therefore the results provided a scientific background for development and utilization of Dysosma plants.
出处
《天然产物研究与开发》
CAS
CSCD
1994年第2期17-20,共4页
Natural Product Research and Development
关键词
鬼臼毒素
分离
鉴定
八角莲
Dusosma plants
Podophyllotoxin
Quantitative determination
