摘要
目的 探讨抑癌基因蛋白表达与前列腺癌临床病理特征和转移的关系。方法 应用免疫组化方法检测 4 5例前列腺癌组织中 p5 3,p16和PTEN抑癌基因蛋白表达。 结果 在前列腺癌组织中 p5 3,p16和PTEN蛋白表达阳率为 4 2 .2 % (19/4 5 )、5 7.8% (2 6 / 4 5 )和 31.1% (14 / 4 5 )。p5 3,p16和PTEN蛋白表达与前列腺癌分级、分期和转移相关 (P <0 .0 5 )。 结论 p5 3。
Objective To study the expression and correlation between expression of tumor suppressor gene and clinical pathotogic character and metastasis in prostatic cancer (Pca). Methods The expression of p53,p16 and PTEN gene protein in 45 cases of Pca was studied with immunohistochemical technique. Results The positive expression rate of p53,p16 and PTEN in Pca was 42.2%(19/45),57.8%(26/45) and 31.1%(14/45),respectively.p53,p16 and PTEN were correlated with the histologic grading and clinical staging of Pca and with metastasis(P<0.05). Conclusion The expression of proteins p53,p16 and PTEN may be a useful tumor marker for evaluating the metastasis and prognosis of Pca.
出处
《山西医科大学学报》
CAS
2005年第1期120-121,共2页
Journal of Shanxi Medical University
