摘要
目的 :探讨 NF- κB、c- Myc、h TERT在鼻咽粘膜慢性炎和鼻咽癌中的表达及意义。方法 :用免疫组化 SP法检测2 7例鼻咽粘膜慢性炎和 30例鼻咽癌中NF- κB、c- Myc、h TERT的表达。结果 :NF- κB、c- Myc和 h TERT在鼻咽粘膜慢性炎组中的阳性表达率分别为 5 5 .5 %、74 .1%和 5 9.3% ;在鼻咽癌组中的阳性表达率分别为 83.3%、93.3%和 90 .0 % ,与鼻咽粘膜慢性炎组比较差异均有显著性 (P<0 .0 1或 P<0 .0 5 ) ;在鼻咽癌中 NF-κB和 c- Myc、NF-κB和 h TERT的表达均呈显著正相关 (分别 P<0 .0 5 ,P<0 .0 1)。结论 :在鼻咽癌中 NF- κB、c- Myc和 h TERT均高表达 ,它们的过表达可能参与了鼻咽癌的发生和发展过程。
Objective:To investigate the expression of NF-κB, c-Myc and hTERT in chronic nasopharyngitis and nasopharyngeal carcinoma (NPC). Methods: Expression of NF-κB, c-Myc and hTERT was detected by immunohistochemical method in 27 patients with chronic nasopharyngitis and 30 patients with NPC. Results: The expression rates of NF-κB, c-Myc and hTERT were 55.5%, 74.1% and 59.3% in chronic nasopharyngitis, and 83.3%,93.3% and 90.0% in NPC, respectively. There were statistical differences in their expression between NPC and chronic nasopharyngitis (P<0.01～0.05). The expression of NF-κB was significantly correlated with that of c-Myc and hTERT in NPC (P<0.01～ 0.05). Conclusion: The overexpression of NF-κB, c-Myc and hTERT could be involved in the development and progression of NPC.
出处
《广东医学院学报》
2005年第1期17-19,共3页
Journal of Guangdong Medical College
