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Galectin-3与糖尿病肾病 被引量：2

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摘要 糖尿病肾病(DN)是糖尿病并发症之一,其发病机制尚未完全清楚,其中晚期糖基化终末产物(AGEs)及其受体在DN中的作用受到了众多学者的关注。Galectin3是一种具有多种生物学作用的半乳糖结合凝集素。新近研究表明galectin3参与构成了AGEs的受体复合物,并且高血糖环境可以诱导galectin3过度表达。推测galectin3可能通过促进AGEs的清除降解、调节AGEs其他受体表达等途径参与了DN发生、发展,减轻AGEs对肾脏组织的损害。
作者 侯志强 蒋玲
机构地区 山东大学齐鲁医院内分泌科
出处 《国外医学（内分泌学分册）》 2005年第2期129-131,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 GALECTIN-3 DN 糖尿病肾病 受体表达 糖基化终末产物 高血糖 糖尿病并发症 凝集素 生物学作用 复合物
分类号 R587.2 [医药卫生—内分泌]
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参考文献12

  • 1Honjo Y, Mangia-Makker P, Inohara H, et al. Down-regulation ofgalectin-3 suppresses tumorigenicity of human breast carcinoma cells.Clin Cancer Res,2001,7:661-668.
  • 2Menon RP, Hughes RC. Determinants in the N-terminal domains ofgalectin-3 for secretion by a novel pathway circumventing the endoplas-mic reticulum-Golgi complex. Eur J Biochem, 1999,264: 569-576.
  • 3Pricci F, Leto G, Amadio L, etal. Role of galectin-3 as a receptor for ad-vanced glycosylation end products. Kidney Int, 2000, 77 (Suppl): S31-S39.
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同被引文献15

  • 1陈国纯,刘伏友.Galectin-3与肾脏疾病的相关研究进展[J].国外医学（泌尿系统分册）,2005,25(2):268-271. 被引量：2
  • 2蒲建章,赵洪洋.Galectin-3在脑肿瘤的研究进展[J].中国微侵袭神经外科杂志,2006,11(3):142-144. 被引量：4
  • 3[1]Razani B,Woodman SE,Lisanti MP.Caveolae:from cell biology to animal physiology[J].Pharmacol Rev,2002,54:431-467.
  • 4[3]Kikuchi Y,Kobayashi S,Hemmi N,et al.Galectin-3-positive cell in filtration in human diabetic nephropathy[J].Nephropathy Dial Transplant,2004,19:602-607.
  • 5[4]Iacobini C,Oddi G,Menini S,et al.Development of age-dependent gl omerular lesions in Galectin-3/AGE-receptor-3 knockout mice[J].Am J Physio l Renal Physiol,2005,289:F611-F621.
  • 6[5]Bichara M,Attmane-Elakeb A,Brown D,et al.Exploring the role of G alectin-3 in kidney function:a genetic approach[J].Glycobiology,2006,16:36 -45.
  • 7[6]Nakagawa T,Sato W,Glushakova O,et al.Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy[J].J Am So c Nephrol,2007,18:539-550.
  • 8[7]Satoh M,Fujimoto S,Haruna Y,et al.NAD(P)H oxidase and uncoupled n itric oxide synthase are major sources of glomerular superoxide in rats with exp erimental diabetic nephropathy[J].Am J Physiol Renal Physiol,2005,288:F1144 -F1152.
  • 9杨国华,刘海鹰.Galectin-3与肿瘤的研究进展[J].中华肿瘤防治杂志,2007,14(22):1755-1758. 被引量：18
  • 10Sharma UC. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction[J].{H}CIRCULATION,2004.3121-3128.

引证文献2

二级引证文献12

国外医学（内分泌学分册）
2005年 第2期

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