期刊文献+

免疫球蛋白在肾移植后肺部感染治疗中的辅助作用 被引量:8

Intravenous immunoglobulin therapy in the pulmonary infection after renal transplantation
原文传递
导出
摘要 目的探讨静脉注射大剂量免疫球蛋白在肾移植后肺部感染治疗中的辅助作用.方法肾移植后发生肺部感染的14例患者,在常规针对病原体治疗基础上辅以静脉注射免疫球蛋白,其中8例给予大剂量免疫球蛋白(A组)7~10 d,6例接受小剂量免疫球蛋白组(B组)3~7 d;另有12例肾移植后发生肺部感染者仅接受针对病原体的治疗(C组).观察各组重症肺部感染发生率,A、B组治疗前后血清IgG、IgA、IgM的浓度以及T淋巴细胞亚群的变化.结果A、B、C组重症肺部感染发生率分别为0、66.7%和66.7%,死亡率为0、16.7%和25.0%;A组治疗后血清IgG浓度升高(P<0.01),并明显高于B组(P<0.01);A、B组治疗前后T淋巴细胞亚群的差异均无统计学意义(P>0.05).结论早期联合静脉注射大剂量免疫球蛋白作为一种辅助治疗,能阻止肾移植后肺部感染的进一步发展,降低重症肺部感染的发生率和死亡率. Objective To evaluate the adjunctive therapeutic effect of intravenous immunoglobulin (IVIG) therapy in the pulmonary infection after kidney transplantation.Methods In 14 cases of pulmonary infection after kidney transplantation, 8 and 6 cases were subjected to high dose (7 to 10 days, group A) or low dose (3 to 7 days, group B) of IVIG therapy besides the standard specific anti-pathogen therapy. In 12 cases of pulmonary infection after kidney transplantation, only standard specific anti-pathogen therapy was given (group C). The incidence and mortality of severe pulmonary infection, levels of serum IgG, IgA, IgM and T lymphocyte subsets among the three groups were observed.Results The incidence of severe pulmonary infection was 0, 66.7 % and 66.7 % respectively in groups A, B and C with the mortality being 0, 16.7 % and 25.0 % respectively. The level of serum IgG was significantly increased in group A after treatment as compared with that before treatment and in group B ( P < 0.01 ). There were no significant differences in T lymphocyte subsets in groups A and B before and after treatment ( P > 0.05 ).Conclusion As an adjunctive therapy, high dose of IVIG at early stage of pulmonary infection can reduce the incidence of severe pulmonary infection and mortality after kidney transplantation.
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2005年第3期148-150,共3页 Chinese Journal of Organ Transplantation
关键词 肾移植 重症肺部感染 免疫球蛋白 治疗中 大剂量 发生率 治疗前后 辅助作用 结论 目的 Kidney transplantation Lung Infection Combined modality therapy Immuno-globulins
  • 相关文献

参考文献7

  • 1朱有华,闵志廉,姚亚成,任吉忠,景炳文.肾移植患者重症肺部感染的诊断与救治[J].中华器官移植杂志,2001,22(1):14-16. 被引量:91
  • 2潘晓鸣,薛武军,田普训,丁小明.肾移植术后肺部感染致急性呼吸窘迫综合征的诊治体会[J].中华器官移植杂志,2003,24(3):189-189. 被引量:9
  • 3Stiehm ER. Human intravenous immunoglobulin in primary and secondary antibody. Pediatr Infect Dis J, 1997, 16:696-707.
  • 4Ronald AS. Intravenous immunoglobulin consensus state ment. J Allergy Clin Immunol, 2001, 108(Suppl 4): 139-145.
  • 5Bilal NE, Gedebou M. Clinical and community strains of Klebsiella Pneumoniae: multiple and increasing rates of anti-biotic resistance in Abha, Saudi Arabia. Br J Biomed Sci, 2000, 57: 185-191.
  • 6Rocha PN, Butterly DW, Greenberg A, et al. Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection.Transplantation, 2003, 75:1490-1495.
  • 7Luke PP, Scantlebury VP, Jordan ML, et al. Reversal of steroid and anti-lymphocyte antibody-resistant rejection using intravenous immunoglobulin (IVIG) in renal transplant recipients,Transplantation, 2001, 72:419-422.

二级参考文献3

  • 1Benedetti E, Sileri P, Pursell KJ, et al. Treatment of severe pneumonia in kidney transplant recipients. Transplant Proc, 2001, 33:3652.
  • 2Prof. G. R. Bernard MD,A. Artigas,K. L. Brigham,J. Carlet,K. Falke,L. Hudson,M. Lamy,J. R. LeGall,A. Morris,R. Spragg. Report of the American-European consensus conference on ARDS: Definitions, mechanisms, relevant outcomes and clinical trial coordination[J] 1994,Intensive Care Medicine(3):225~232
  • 3朱有华,张明,盛茂,周庭银.肾移植患者细菌谱的调查及耐药性的研究[J].中华器官移植杂志,2002,23(2):104-105. 被引量:33

共引文献96

同被引文献66

引证文献8

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部