摘要
关于乙肝病毒感染与先天畸形关系的研究多着眼于病毒本身及其抗原。作者在回顾性研究中发现抗－ＨＢｓ可能与先天畸形发生有关。本文前瞻性队列研究结果表明，抗－ＨＢｓ阳性母亲的新生儿畸形发生率（３．１６％）显著高于抗－ＨＢｓ阴性母亲（１．３５％），Ｐ＝０．０１４１，再次证实抗－ＨＢｓ可能有致畸作用。随乙肝疫苗广泛接种，育龄妇女抗－ＨＢｓ阳性率越来越高，因此进一步探讨抗－ＨＢｓ致畸作用十分重要。
All of the studies on the relation between HBV infectiOn and congenital malformation focused on HBV itself and its antigen. We foundthat anti-HBs in mothers' bodies was related to newborn congenital malformation three years ago.This prospective study was carried out in order to confirm the role of anti-HBs in the development of congenital malformation. The result showed that the incidence of newborn congenital malformation in mothers positive for anti-HBs (3. 16%) was much higher than that in mothers negative for anti-HBs (1. 35%) , P= 0. 0141 , confirming that anti-HBs might have teratogenic effect. As hepatitis B vaccine is used widely, it is important to further study the
出处
《西安医科大学学报》
CSCD
1994年第3期235-237,240,共4页
Journal of Xi'an Medical University(Chinese)
基金
国家自然科学基金
关键词
表面抗原
先天畸形
乙型肝炎
新生儿
Hepatitis B virus infection, anti-HBs, congenital malformation
