复方甘草酸苷治疗慢性乙型肝炎的疗效观察被引量：11

Observation of the Therapeutic Effect of the SNMC on Chronic HBV

下载PDF

导出

摘要目的 :观察复方甘草酸苷治疗慢性乙型肝炎的疗效。方法 :将126例慢性乙型肝炎患者随机均分为复方甘草酸苷组 (治疗组 )和门冬氨酸钾镁组 (对照组 ) ,给予相应治疗后分别观察3wk、3mo和6mo时患者的临床症状、肝功能及电解质变化情况。结果 :治疗3wk时治疗组的临床症状、天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、γ -谷氨酰转移酶、总胆红素恢复明显优于对照组 (P<0. 01) ,治疗3mo、6mo时治疗组的复发率明显低于对照组 (P<0. 01) ;治疗3wk时两组均未见明显低钾及水钠潴留的发生。结论 :复方甘草酸苷对治疗慢性乙型肝炎有较好疗效。 OBJECTIVE:To observe the therapeutic effect of the SNMC on HBV.METHODS:126 patients were randomly divided into SNMC group(treatment group) and potassium magmesium aspartate group(control group),the clinic symptoms,liver functions and electrolytes changes of each group were observed respectively after the corresponding treatments for 3 weeks,3 months and 6 months.RESULTS:The clinic symptom,the recovery of AST,ALT,γ-GTP,SB of the SNMC group were obviously better than the control group(P<0.01),the recurrent rate in 3 months,6 months for the SNMC group was apparently lower than the control group(P<0.01);neither remarkable hypopotassaemia nor water-sodium retention were found after treatment for 3 weeks.CONCLUSION:SNMC has obvious clinical effects on chronic HBV.

作者李健李琼

机构地区四川省川北医学院附属医院四川省西华师范大学医院

出处《中国药房》 CAS CSCD 北大核心 2005年第6期451-453,共3页 China Pharmacy

关键词肝炎病毒乙型复方甘草酸苷临床疗效 Hepatitis virus B Hepatitis SNMC Clinical therapeutic effect

分类号 R978.7 [医药卫生—药品] R975 [医药卫生—药品]

引文网络
相关文献

参考文献4

1中华医学会传染病与,寄生虫病学分会,肝病学分会.病毒性肝炎防治方案[J].中华肝脏病杂志,2000,8(6):324-329. 被引量：14012
2汪俊韬,于少军,肖炜.复方甘草甜素(美能)在肝病领域的临床应用[J].中国药房,2002,13(8):500-502. 被引量：148
3Takaharu Y, Toxhiaki N, Yoshio S, et al.Effects of glycyrrhizin on glucocoryicoid signaling pathway in hepatocytes[J].Digestive Disease and Sciences, 2002, 42( 8): 1 775.
4Kroes BH, Beukdman CJ, Vandenberg AJJ, et al.Inhibition of human complement by β- glycyrrhetinic acid[J].Immunology, 1997, 90: 115.

二级参考文献11

1[1]Hiromitsu Kumada.Long- term treatment of chronic hepatitis C with glycyrrhizin[stronger neo- minophagen C(SNMC)] for preventing liver cirrhosis and hepatocellular carcinoma[J]. Oncology, 2002,62,(1):94.
2[2]Ohtsuki K.Separation of phospholipase A2 in Habu snake venom by glycyrrhizin(GL)- affinity column chromatography and identification of a GL- sensitive enzyme[J]. Biol Pharm Bull, 1998,21:574.
3[3]Shimoyama Y.Physiological correlation between glycyrrhizin,glycyrrhizin- binding lipoxygenase and casein kinase Ⅱ [J].FFBS Lett, 1996,391:238.
4[4]Zhang Y.Bidirectional control by glycurrhizin of the growth response of lymphocytes stimulated through a receptor- bypassed pathway[J]. Immunol Lett ,1992,32:147.
5[5]Kimura M.Selective activation of extrathymic T cells in the liver by glycyrrhizin[J]. Biotherapy ,1992,5:167.
6[6]Takahara T,Watanabe A, Shiraki K.Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study[J]. J Hepatol, 1994,21:601.
7[7]Sato H, Goto W, Yamamura J.Therapeutic basis of glycyrrhizin on chronic hepatitis B[J]. Antivir Res,1996,30:171.
8[8]Iino S.Therapeutic effects of stronger neo- minopha_ gen C at different doses on chronic hepatitis and liver cirrhosis[J]. Hepatol Res ,2001,19:31.
9[9]MacKenzie MA.The influence on glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers[J]. J Clin Endocrinol Metab ,1990,70:1 637.
10河边博史ほか.アルドステロン症、伪アルドステロン症[J].循环科学,1996,(16):224.