摘要
目的 观察六味地黄丸对激素治疗肾病综合征的干预作用。方法 两组均给予泼尼松首始剂量1mg／(kg·d),晨8:00顿服,持续8-12周后,每2周减5.0mg,至0.5mg／(kg·d)时,改为2天剂量合并隔日顿服,再以每2-3周减5.0mg,至0.4mg／(kg·2d)时维持6-12个月,并给予必要的对症处理。治疗组同时加服六味地黄丸每次8粒,每天3次,至泼尼松减至维持量时。结果 治疗组疗效显著优于对照组(P<0.05);24h尿蛋白定量,血浆白蛋白、甘油三酯(TG)、总胆固醇(TC)等指标两组均改善显著(P<0.05,P<0.01),但均以治疗组为优(P<0.05);其复发率亦以治疗组为低(P<0.05)。治疗组出现的阴虚火旺证候积分值及不良反应的发生率均较对照组为低(P<0.05,P<0.01)。结论 六味地黄丸能显著提高激素对肾病综合征的疗效、减少其复发,并能对抗激素的不良反应。
To observe the intervention of Liuwei Dihuang pill (LDP) on therapeutic effectiveness and adverse reaction of hormonotherapy in treating nephrotic syndrome. Methods Patients allocated in two groups were medicated with initial dose of prednisone 1 mg/kg once a day at 8 am in the morning. After being medicated for 8 to 12 weeks, the dose of prednisone was decreased by 5. 0 mg every 2 weeks till 0.5 mg/kg per day. Then the medication was changed to that two days dosage orally take once a day with the daily dose reduced by 5.0 mg/kg every 2 to 3 weeks, and maintained at 0.4 mg/kg once every two days. At same time, necessary symptomatic treatment was given. To the treated group oral administration of LDP 8 capsules was given additionally, 3 times per day until prednisone decreased to maintenance dose. Results Therapeutic effect in the treated group was significant better than that in the control group (P<0.05). Urinary protein, plasma albumin, triglyceride (TG) and total cholesterol (TC) in both groups were obviously improved (P<0.05 or P< 0 .01). However, as compared with the control group, the improvement was better, and the recurrent rate was lower (P < 0.05) in the treated group. Scores of Yin-deficiency caused excessive Fire syndrome and incidence rate of adverse reaction in the treated group were lower than those in the control group (P<0.05 or P<0.01). Conclusion LDP can markedly improve the therapeutic effectiveness and counteract the adverse reaction of hormonotherapy in treating nephrotic syndrome, and reduce the recurrence of the disease.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2005年第2期107-110,共4页
Chinese Journal of Integrated Traditional and Western Medicine
