摘要
目的 探讨白细胞介素 12(IL 12)和白细胞介素 13(IL 13)水平对儿童哮喘的影响。方法 用酶联免疫吸附 试验(ELISA)测定58例轻、中度哮喘急性发作期患儿经丙酸倍氯米松治疗前后及20例正常儿童的血清IL 12和IL 13水平, 同时用肺功能仪测定其1s用力呼吸容积(FEV1.0),并分析其相互关系。结果 哮喘急性发作期患儿治疗前及治疗后的IL 12 水平与FEV1.0占预计值百分数(FEV1.0pre)明显低于健康对照组,IL 13水平明显高于健康对照组(均P<0.01);治疗前IL 12 水平与FEV1.0pre均明显低于治疗后,IL 13水平明显高于治疗后(均P<0.05)。IL 12水平与FEV1.0pre呈正相关(P<0.05,r= 0.495),与IL 13水平呈负相关(P<0.05,r=-0.519);IL 13水平与FEV1.0pre呈负相关(P<0.05,r=-0.527)。结论 IL 12 与IL 13可能是哮喘发病的重要因素之一,其可为哮喘的诊断及判断病情提供较好的实验室参数。
Objective To discuss the influence of IL-12/13 level on asthma in children.Methods Serum IL-12/13 levels were determined by ELISA before and after betamethasone dipropionate treatment in 58 children with mild or moderate acute episode asthma. The FEV 1.0 was tested by using pulmonary function meter. Twenty normal children served as controls. The changes in IL-12/13 levels before and after treatment, and their relations with FEV 1.0pre were analyzed. Results IL-12 level and FEV 1.0pre before and after treatment were obviously lower, while IL-13 level were higher than healthy controls (P< 0.01 ). IL-12 level and FEV 1.0pre before treatment were obviously lower, while IL-13 level were higher than that after treatment (P< 0.05 ). IL-12 level was positively related with FEV 1.0pre (P< 0.05 , r= 0.495 ), but negatively with IL-13 (P<0.05, r= -0.519 ). IL-13 level was negatively related with FEV 1.0pre (P< 0.05 ,r= -0.527 ).Conclusion IL-12 and IL-13 may be one of the factors causing bronchial chronic inflammation and can be used as parameters for the diagnosis and judgment of asthma.
出处
《华中医学杂志》
2005年第1期29-30,共2页
Central China Medical Journal
