摘要
目的 :探讨肿瘤转移相关基因在子宫腺肌症发生中的作用。方法 :采用免疫组织化学方法 ,对 4 3例子宫腺肌症患者、2 2例对照组 (正常子宫内膜 )的nm2 3-H1、基质金属蛋白酶 - 2 (MMP - 2 )、基质金属蛋白酶 - 9(MMP - 9)、膜型 1-基质金属蛋白酶 (MT1-MMP)和基质金属蛋白酶组织抑制因子 - 1(TIMP - 1)的表达进行研究。结果 :子宫腺肌症中 ,MMP - 2、MMP - 9和MT1-MMP的表达水平明显高于对照组 (P <0 0 1) ,nm2 3-H1和TIMP - 1的表达水平无显著差异 (P >0 0 5 )。结论 :MMP - 2、MMP - 9和MT1-MMP在子宫腺肌症的发病过程中可能起重要的作用。
AIM: To study the tumor metastasis-related genes expression in adenomyosis and normal endometrium in order to investigate the pathogenesis of adenomyosis. METHODS: 43 specimens of adenomyosis, 22 specimens of controls (normal endometrium) were studied. The expressions of nm23-H1, MMP-2, MMP-9, MT1-MMP, and TIMP-1 in adenomyosis and controls were detected by immunohistochemical method. RESULTS: The expression levels of MMP-2, MMP-9, and MT1-MMP in adenomyosis were significantly higher than those in controls ( P <0 01), but there were no significant difference in nm23-H1 and TIMP-1 ( P >0 05). CONCLUSION: MMP-2, MMP-9, especially MT1-MMP, maybe play an important role in the pathogenesis of adenomyosis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2005年第3期541-544,共4页
Chinese Journal of Pathophysiology
基金
安徽省教育厅自然科学研究项目 (No .2 0 0 3kj313)
