摘要
【目的】探讨血清一氧化氮 (NO)及一氧化氮合酶 (NOS)水平与病毒性肝炎的关系。【方法】作者检测了 5 9例病毒性肝炎患者的血清NO及NOS水平。【结果】各型肝炎患者的NO含量均显著高于正常对照组 (P <0 .0 1) ,NOS含量以肝硬化 (LC)、急性肝炎 (AVH)、重型肝炎 (HG)增高显著 (P <0 .0 1) ,其中以LC组增高最为明显。在急性、慢性、重型肝炎的急性期或活动期时 ,NO含量与谷丙转氨酶 (ALT)及总胆红素 (TBIL)呈正相关。【结论】肝脏发生炎症时 ,NOS被诱导生成增多 ,从而产生大量的NO。NO含量升高与肝功能损害的程度有关。重症肝炎时 ,由于肝细胞大量坏死 ,导致NOS降低 ,NO生成也相应减少。肝硬化患者的血清NO及NOS增高 。
To explore the relationship between serum levels of nitric oxide (NO) / nitric oxide synthase (NOS) and viral hepatitis.The serum levels of NO and NOS in 59 cases with viral hepatitis (VH) were detected.The serum levels of NO in various types of hepatitis were significantly higher than those in normal controls(P<0.01), whereas the NOS activities in patients with liver cirrhosis (LC), acute viral hepatitis(AVH) and severe hepatitis(SH) increased distinctly, but most prominent in LC group. In the acute or active periods of acute , chronic and severe hepatitis, their serum levels of NO were positively correlated to the alanine aminotransferase(ALT) activity and total bilirubin (TBIL) level.[Conclusions]When inflammation occurs in liver, the synthesis of NOS is induced to increase, so a lot of NO is produced. The increased level of NO is closely related with the degree of damage to liver function. Owing to the massive necrosis of liver cells in SH, the NOS activities decline with reduced NO production. The raised serum levels of NO and NOS in LC patients may be mainly related to the release of endotoxin.
出处
《医学临床研究》
CAS
2004年第10期1108-1110,共3页
Journal of Clinical Research
