摘要
目的: 探讨特发性肺纤维化(IPF)患者血清Ⅲ型前胶原(PCⅢ)和层粘连蛋白(LN)水平与临床病情程度的关系。方法: 对29例已确诊的IPF患者进行呼吸困难程度调查、拍摄常规胸片、检查血气及运动肺功能后得出临床影像生理(CRP)评分,根据CRP评分系统将患者分为低分组、高分组,与健康对照组同时测定血清PCⅢ和LN水平,并对各组PCⅢ、LN水平进行比较。结果: (1)CRP评分与PCⅢ测量值作等级相关分析,相关系数rs′=0.723 8(P<0.01),呈正相关关系。低分组与对照组血清PCⅢ水平相比差异无统计学意义(P=0.582 3),高分组与对照组、低分组相比差异均有统计学意义(P<0.01)。(2) CRP评分与LN测量值作等级相关分析,相关系数rs′=0.622 7(P<0.05),呈正相关关系。血清LN水平低分组与对照组相比差异有统计学意义(P<0.01),高分组与低分组相比差异有统计学意义(P<0.01)。结论: 应用CRP评分系统可评估IPF患者病情程度,血清PCⅢ及LN水平可作为评价肺间质病变活动性的重要的无创性指标。
Objective: To explore clinical value of type Ⅲ procollagen peptide PCⅢ and laminin in serum of patients with idiopathic pulmmary fibrosis. Methods: A composite clinical radiographic physiologic(CRP) scoring system was cited, 29 patients with idiopathic pulmonary fibrosis were divided into 2 groups according to CRP scoring system: low score group, high score group. The serum concentrations of PCⅢ and laminin were measured in patients and the control group. Results: The CRP score determination correlated with the serum concentration of PCⅢ (r=0.723 8, P<0.01), The PCⅢ of high score group was significantly higher than that of control group (P<0.001), and was significantly higher than that of low score group (P<0.01). The CRP score showed a significant correlation with the concentration of LN (r= 0.622 7 , P<0.05). Conclusion: Serum concentrations of PCⅢ and LN in patients with idiopathic pulmonary fibrosis are important parameters in evaluating activity of interstitial lung involvement.
出处
《新疆医科大学学报》
CAS
2005年第2期136-138,共3页
Journal of Xinjiang Medical University
