摘要
目的 Meta 分析不可切除肝细胞癌采用介入化疗栓塞(TACE)治疗的疗效。方法 采用关键词“hapatocellular carcinoma”,“liver cell carcinoma”,“randomized controlled trail [RCT]”和chemoembolization”, 对MEDLINE及CNKI中文数据库进行检索,时间为1990-2003年,采用手工检索予以补充。所有13个RCT,都采用Meta 分析整合数据。结果 TACE治疗能显著增加总体的1及2年生存率(OR:0 54;95%CI:0 33,0 89;P=0 015)。采用栓塞(TAE)治疗的病人的生存率显著高于那些采用经动脉灌注化疗(TAC)的生存率(OR:0 72;95%CI:0 53,0 98;P=0 039)。结论 与对症治疗相比,采用TACE治疗肝癌,能显著增加中晚期病人的 1 及 2 年生存率,治疗的关键在于术中栓塞。
Objective To review the available evidence of chemoembolization for unresectable hepatocellular carcinoma (HCC). Methods Computerized bibliographic searches using the hepatocellular carcinoma', 'liver cell carcinoma', 'randomized controlled trial (RCT)' and 'chemoembolization' were performed with MEDLINE and CNKI databases. Meanwhile, they supplemented by manual searches. All 13 RCTs were pooled from meta regression analysis. Results Chemoembolization significantly increased the overall 1 and 2 year survival rates (odds ratio, 0 54;95% CI: 0 33, 0 89;P=0 015) as compared with non active treatment. Analysis of comparative RCTs helped to predict that the overall survival rate was significantly higher in patients treated with transarterial embolization (TAE) than in those treated with transarterial chemotherapy (odd ratio, 0 72;95% CI: 0 53, 0 98;P=0.039). Conclusions In patients with unresectable HCC, chemoembolization significantly improves the overall 1 and 2 year survival rates as compared with non active treatment. The vital step is the embolization during operation.
出处
《中华肝胆外科杂志》
CAS
CSCD
2005年第2期83-86,共4页
Chinese Journal of Hepatobiliary Surgery
