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P53家族新成员P63 被引量：1

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摘要 　　　p53 基因作为广泛存在的肿瘤抑制基因,在肿瘤发生发展中起着重要作用。最近发现两类与 P53 蛋白具有较大同源性的家族成员:P63 和P73。它们都能激活 P53 相关靶基因,抑制增殖,诱导凋亡,但它们在肿瘤发生及细胞生长发育的调控中各自起着既相关又特别的作用。
作者 钱海龙 刘瑞 唐岩
机构地区 第二军医大学长海医院普外科
出处 《中华肝胆外科杂志》 CAS CSCD 2005年第2期139-141,共3页 Chinese Journal of Hepatobiliary Surgery
关键词 肿瘤发生 P53家族 生发 诱导凋亡 家族成员 p53基因 P53蛋白 同源性 调控 发育
分类号 R730.23 [医药卫生—肿瘤]
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参考文献19

  • 1De Laurenzi V,Rossi A,Terrinoni A, et al.P63 and P73 transactivate differentiation gene promoters in human keratinocytes. Biochem Biophys Res Commun, 2000,273: 342-346.
  • 2Lu P, Barad M, Vize PP,et al. Xenopus p63 expression in early ectoderm and neurectoderm. Mech Dev, 2001,102: 275-278.
  • 3Bokhoven H,Hamel BC, Brimshed M, et al. P63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation. Am J Hum Genet, 2001, 69: 481-492.
  • 4Noszczyk BH, Majewski ST. P63 expression during normal cutaneous wound healing in humans. Plast Reconstr Surg, 2001, 108: 1242-1250.
  • 5Sasaki Y,Morimoto I, Ishida S ,et al. Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer. Gene Ther, 2001, 8: 1401-1408.
  • 6Senoo M,Matsumura Y, Habu S, et al. Identification of a novel retrovirus long terminal repeat (LTR) that is targeted by p51A (TAp63gamma) and selective dominant-negative activity of p73L (DeltaNp63al-pha) toward p53-responsive promoter activities. Biochem Biophys Res Commun, 2001, 286: 628-634.
  • 7Dohn M, Zhang S, Chen X, et al. P63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene, 2001, 20: 3193-3205.
  • 8Liefer KM,Koster MI. Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res, 2000, 60: 4016-4020.
  • 9Katoh I, Aisaki KI, Rurata SI, et al. P51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation. Oncogene, 2000, 19: 3126-3130.
  • 10Kadakia M, Slader C, Berberich SJ, et al. Regulation of p63 function by Mdm2 and MdmX. DNA Cell Biol, 2001, 20: 321-330.

同被引文献6

  • 1Mills AA, Zheng B, Wang XJ. p63 is a p53 homologue required for limb and epidermal morphogenesis [ J ]. Nature, 1999,398 (6729) : 708 - 713.
  • 2Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities[J]. Mol Cell, 1998, 2(3) :305 - 316.
  • 3Ikawa S, Nakagawara A, Lkawa Y. p53 family genes: structural comparison, expression and mutation[J]. Cell Death Differ, 1999,6 (12) : 1154 - 1161.
  • 4Kaufmann O, Fietze E, Mengs J, et al, Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas[ J]. Am J Clin Pathol, 2001,116(6) : 823 - 830.
  • 5Pellegrini G, Dellambra E, Gollsano O, et al. p63 identifies keratinocyte stem cells[J]. Proc Natl Acad Sci USA, 2001,98(6): 3156 - 3161.
  • 6Camilo R, Capelozzi VL, Siqueira SA, et al. Expression of p63, keratin 5/6, keratin 7, and surfactant-A in non-small cell lung carcinomas[J]. Human Pathology, 2006, 37(5):542-546.

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中华肝胆外科杂志
2005年 第2期

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