摘要
目的 探讨中国人群p73基因 5’UTR区域两个单核苷酸多态性 (G4C14 ,A4T14 )与肺癌的关系。方法 采用病例对照研究 ;选择经组织学确诊的肺癌病例 4 2 5例 ,地区、年龄和性别频数匹配的对照 5 88名 ,以聚合酶链反应 单链构象多态性方法进行多态性检测。结果 此两个多态性之间具备完全的连锁不平衡 ,AT(A4T14 )单倍型在病例组显著少于对照组 (0 .2 2 5vs.0 .2 87,P =0 .0 0 18) ,提示变异的AT单倍型对肺癌具有保护作用。与携带p73GC GC单倍型基因型者比较 ,携带GC AT单倍型基因型者肺癌风险降低 30 % (OR =0 .70 ,95 %CI:0 .5 3～ 0 .92 ) ,而携带AT AT单倍型基因型者肺癌风险降低 5 5 % (OR =0 .70 ,95 %CI:0 .2 6～ 0 .80 )。结论 p73基因多态改变可能与中国汉族人群肺癌遗传易感性有关。
Objective To study the relationship between two potential functional polymorphisms in exon 2 of the p73 gene and the susceptibility of lung cancer. Methods Genotypes were determined by polymerase chain reaction-single stand conformation polymorphism(PCR-SSCP) method in 425 histologically-confirmed lung cancer cases and 588 cancer-free controls, frequency-matched by age and sex. Results The two polymorphisms were in complete linkage disequilibrium and the frequencies of variant p73 AT haplotype (A4T14) were less commonly seen in the cases ( 0.225 ) than in the controls ( 0.287 ) ( P = 0.0018 ). Compared with the p73 GC/GC homozygotes,both the AT/AT variant homozygotes and GC/AT heterozygotes were associated with a significantly decreased risk [adjusted odds ratio ( OR )= 0.45 ,95% confidence interval ( CI )= 0.26- 0.80 and OR = 0.70 ,95% CI = 0.53- 0.92 ,respectively]. Conclusion These results suggested that this p73 dinucleotide polymorphism might have had a role to play in the susceptibility of lung cancer.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2005年第2期106-109,共4页
Chinese Journal of Epidemiology
基金
国家"973"重大基础研究基金资助项目(2 0 0 2CB5 12 90 2 )
国家自然科学基金资助项目 (3 0 3 712 40 )
