期刊文献+

c-kit在胃肠道间质瘤中的表达及临床意义 被引量:5

下载PDF
导出
摘要 目的 :通过对胃肠道间质瘤 ( GIST)中原癌基因 c- kit表达的检测 ,探讨 c- kit在GIST中的诊断及临床意义。方法 :用 c- kit、CD34等抗体通过免疫组织化学En Vision法对胃肠道间质瘤进行检测 ,并与平滑肌瘤、神经鞘瘤进行对照研究。结果 :40例 GIST中 c- kit阳性表达率为 97.5 %。CD34阳性表达率为 67.5 %。S- 1 0 0、SMA分别呈 1 7.5 %、1 2 .5 %阳性表达。结蛋白呈阴性表达 ,平滑肌瘤、神经鞘均呈阴性表达。结论 :c- kit作为一种胃肠道间质瘤十分敏感的标记物 ,性能优于 CD34,对 GIST的诊断、鉴别诊断有重要意义。
出处 《陕西医学杂志》 CAS 北大核心 2005年第3期311-313,共3页 Shaanxi Medical Journal
  • 相关文献

参考文献13

  • 1Sircar K. Hewlett BR. Huizinga JD,et al. Interstitial cell of Cajal as precursors for gastrointestinal stromal tumors. Am J Surg Pathol,1999;23: 377.
  • 2Kindbloln LC. Remotti HE, Aldenborg F, et al.Gastrointestinal pacemaker cell tumor (GIPACT):gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol,1998;152 : 1259.
  • 3Lewin KJ. Riddell RH, Weinstein WM, et al.Gastrointestinal pathology and its clinical implicstions. Gastroenterology, 1992; 103: 284.
  • 4Hirota S, Isaki K, Moriiyama Y, et al. Gain-offunction mutation of C-Kit in human gastrointestinal stromal tumors. Science, 1998; 279: 577.
  • 5Graadt van Roggen JF, Velthuysen ML, Hogendoorn PC. The histopathological differemial diagnosis of gastrointestinal stromal tulnors. J Clin Pathol. 2001;54: 96.
  • 6Suster S. Fisher C. Immunoreactivity for the human hematopoietic progentor lell antigen (CD34)in lipomatous tumors. Am J Surg Path01. 1997;21: 195.
  • 7Miettinen M, Sarlomo-Rikala M, Lasota J.Gastrointestinal stromal tumors:recent advances in understanding of their biology. Hum Pathol, 1999; 30: 1213.
  • 8Sarlomo-Rikala M. Kovatich AJ. Barusevicius A. et al. CD117: a sensitive marker for gastrointestinal stromal tumors that is more specific than CD34,Mod Pathol,1998;ll : 728.
  • 9Mosksluk CA,Tian Q,Marshall CR,et al. Mutations of c-kit JM domain aree found in a minority of human gastrointestinal stromal tumors. Oneogene, 1999; 18: 1897.
  • 10Lasota J, Jasinski M, Sarlomo Rikala M, et al.Mutations in exon Ⅱ of c-kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas. Am J Pathol, 1999 ; 154 : 53.

同被引文献68

引证文献5

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部