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原发性肝癌中STAT1,STAT2与hMLH1,hMSH2的表达关系 被引量：3

Relationship of expression between STAT1,STAT2 and hMLH1,hMSH2 in hepatocellar carcinoma
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摘要 　　目的　探讨肝细胞癌中STAT1,STAT2与hMLH1,hMSH2的表达关系及意义。方法　利用SABC免疫组织化学方法检测 3 7例原发性肝癌及癌旁组织标本中的STAT1,STAT2,hMLH1,hMSH2蛋白的表达。结果　HCC组织中STAT1,STAT2 ( 2. 3 0±1. 8 1, 2. 4 9±2. 1 3 )和hMSH1,hMSH2 ( 2. 2 4±1. 7 7, 1. 6 5±1. 7 0 )蛋白阳性率和阳性信号显著低于癌旁肝组织 ( 3. 7 3±0. 9 9, 3. 6 2±1. 8 5, 3. 3 8±1. 3 2, 3. 30±1. 3 7 ) (P < 0. 0 5 ); 4种蛋白活性在癌组织的分化程度中高分化阳性表达 ( 4. 1 5±2. 4 5, 4. 35±2. 4 5, 3. 5 2±1. 7 3, 4. 3 9±1. 5 0 )显著高于低分化者 ( 1. 8 0±2. 2 0, 2. 0 3±2. 1 4,1. 78±1. 6 2, 1. 5 8±1. 8 4 ) (P< 0. 0 5 ),癌旁组织中STAT1与hMSH2,STAT2与hMLH1,hMSH2表达呈正相关 (P< 0. 0 5, P< 0. 0 1 )。结论　STAT1,STAT2和hMLH1,hMSH2均可能在细胞早期的恶性转化中起重要作用。 Objective To study the significance and expression relationship among STAT1,STAT2 and hMLH1 ,hMSH2 proteins in hepatocellur carcinoma(HCC). Methods SABC immunohistochemistry method was used to detect the expression of STAT1,STAT2,hMLH1 and hMSH2 proteins in cancer tissues and paracancer tissue from 37 patients of HCC. Results The positive rates and expressive levels of STAT1,STAT2,and hMLH1, hMSH2 in HCC was significantly lower than those in paracancer liver tissues(P< 0.05 ). The level of expression of the 4 proteins in well differented cancer tissue was significanty higher than that in poorly differentiated cancer tissue(P<0.05). A positive correlation was found for STAT1 and hMSH2 ,STAT2 and hMLH1 ,hMSH2 (P<0.05) in paracancer liver tissues. Conclusions The data suggest that STAT1,STAT2 and hMLH1,hMSH2 may play an important roie in the early stage of malignant transformation of hepatocytes.
作者 周钧 钟德玝 华颂文 戴卫东 易石坚
机构地区 中南大学湘雅二医院普通外科
出处 《中国普通外科杂志》 CAS CSCD 2005年第2期100-103,共4页 China Journal of General Surgery
关键词 肝肿瘤/病理学 肝细胞瘤/病理学 基因表达 信号传导和转录激活因子 错配修复蛋白 LIVER NEOPLASMS/pathol HEPATOMY/pathol GENES EXPRESSION STAT hMLH1 hMSH2
分类号 R735.7 [医药卫生—肿瘤] R730.261 [医药卫生—肿瘤]
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参考文献9

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共引文献56

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二级引证文献7

中国普通外科杂志
2005年 第2期

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