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^(125)I放射粒子植入结合雄激素全阻断治疗中晚期前列腺癌 被引量：4

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摘要 目的探讨经直肠超声引导下125I放射粒子植入结合雄激素全阻断治疗中晚期前列腺癌的临床价值。方法病例30例,其中C期23例,D期7例,行直肠B超引导下,经会阴穿刺前列腺125I放射粒子植入及双例睾丸切除术,术后1w服用抗雄激素药物,其中D期患者,术后1月行转移灶外放疗。结果30例手术顺利,平均植入125I放射粒子68粒,平均手术时间90min,平均住院时间6d。术后随访平均16个月,完全反应22例,部分反应5例,病情稳定2例,病情恶化1例,PSA无进展生存率97%(29/30),无1例出现严重的并发症。结论125I放射粒子植入结合雄激素全阻断治疗中晚期前列腺癌安全、微创、并发症发生率低、疗效肯定。
作者 黄毅 马潞林 王俊杰 冉维强
机构地区 北京大学第三医院泌尿外科 北京大学第三医院肿瘤放疗科 北京大学第三医院超声科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2005年第3期267-268,共2页 Chinese Journal of Gerontology
关键词 ^125I放射粒子 雄激素全阻断 中晚期前列腺癌
分类号 R737.25 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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同被引文献38

  • 1黄振国,张雪哲,王武,洛小林,王继英.CT导引下^(125)I粒子植入在治疗恶性肿瘤中的应用[J].中华放射学杂志,2004,38(9):921-925. 被引量：135
  • 2黄毅,王俊杰,冉维强,马璐林,陈忠新.前列腺^(125)Ⅰ射粒子植入结合去势治疗C期前列腺癌(附10例报告)[J].肿瘤防治研究,2004,31(12):770-772. 被引量：2
  • 3王国民,徐志兵,朱延军,徐叶青,陈绍亮,曾昭冲,程文英.^(125)I放射性粒子永久植入治疗前列腺癌[J].中华泌尿外科杂志,2005,26(4):263-266. 被引量：18
  • 4陈明,孙则禹,张古田,陈恕求,李俊龙,彭涛,戴玉田.经会阴^(125)I粒子组织间植入治疗局限性前列腺癌临床研究(附10例报告)[J].现代泌尿外科杂志,2007,12(2):101-103. 被引量：7
  • 5WHITMORE WF JR, HILARIS B, GRABSTALD H. Retropubic implantation of iodine 125 in the treatment of prostatic cancer[J]. J Urol, 1972, 108-118.
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  • 8MITCHELL DM, SWINDELL R, ELLIOTT T, et al. Analysis of prostate-specific antigen bounce after I 125) permanent seed implant for localised prostate cancer [J]. Radiother Oncol. 2008, 88 (1): 102-107.
  • 9PRADA PJ, GONZALEZ H, FERNANDEZ J, et al. High-dose-rate intensity modulated brachytherapy with external-beam radiotherapy improves local and biochemical control in patients with high-risk prostate cancer [J]. Clin Transl Oncol, 2008, 10(7): 415--421.
  • 10CHEN YC, CHUANG CK, HSIEH ML, et al. High-dose-rate brachytherapy plus external beam radiotherapy for T1 to 33 prostate cancer: an experience in Taiwan [J]. Urology,2007,70(1) 101-105.

引证文献4

二级引证文献4

中国老年学杂志
2005年 第3期

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