摘要
目的:研究螺旋藻对大鼠实验性变应性鼻炎的治疗作用。方法:用卵清蛋白致敏大鼠制成变应性鼻 炎动物模型,口服螺旋藻治疗,观察其行为学差异;用组织病理学方法观察鼻黏膜改变及肥大细胞脱颗粒;用酶联 免疫吸附法(ELISA)检测血清总IgE水平;用荧光法检测血清组胺含量。结果:行为学得分,螺旋藻治疗组明显低 于阴性对照组,差异有统计学意义(P<0.01);鼻黏膜炎性反应明显轻于阴性对照组;鼻黏膜肥大细胞总数、脱颗粒 数和血清总IgE、组胺含量明显低于阴性对照组(P<0.01);螺旋藻治疗组、阳性对照组(强的松治疗组)和正常对 照组之间差异无统计学意义(P>0.05)。结论:螺旋藻可防治大鼠变应性鼻炎的发生,提示螺旋藻可用于临床治疗 变应性鼻炎。
Objective To determine the therapeutic effect of spirulina platensis in allergic rhinitis(AR). Methods Ovalbumin sensitized white rats used as AR animals were treated with spirulina platensis (SPP). At the end of the treatment, the differences in the behavior science were observed; the changes in the nasal mucosa and mast cell degranulation were studied pathologically; and the levels of serum histamine and total immunoglobulin (Ig)E were determined by enzyme-linked immune sorbent assay. Results The behavior science score of the SPP treatment group was lower than that of the negative control group (P<0.01); inflammatory reaction of nasal mucosa in the SPP treatment group were remarkably relieved; the number of nasal mucosa mastocyte and mast cell degranulation in the SPP treatment group were lower than that of the negative control group (P<0.01). The levels of serum histamine and total IgE in the SPP treatment group were lower than that of the negative control group (P<0.01). It had no significant difference in the positive control group and the SPP treatment group and the blank control group (P>0.05).Conclusion Spirulina platensis can prevent and treat AR in rats, which implies the possibility of using spirulina platensis for AR patients in the future.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2005年第1期96-98,共3页
Journal of Central South University ：Medical Science
基金
湛江市科委攻关项目(2001 85)
