摘要
目的:探讨黄芪治疗多柔比星(Doxorubicin)肾病大鼠的病理学基础。 方法:用图像分析系统测量多柔比星肾病大鼠肾小球面积、系膜区面积和系膜细胞数。 结果:系膜区面积和系膜细胞数在肾病组中最大,与治疗组和正常对照组比差异有显著性意义(P<0. 01),治疗组与正常对照组之间也存在显著性差异(P<0. 05)。三组之间系膜区面积 /肾小体面积、系膜细胞数 /肾小体面积和系膜细胞数 /系膜区面积差异均有显著性意义。相关分析提示,注射多柔比星 4周时系膜区面积和系膜细胞数与尿蛋白、血清胆固醇及三酰甘油呈正相关(P<0. 01),与血清清蛋白呈负相关(P<0. 01)。 结论:黄芪通过影响系膜区和系膜细胞而对多柔比星肾病产生治疗作用。
Objective: To elucidate the patholgy of Doxorubicin nephropathy treated with astragalus membranaceus in rats. Methods: The glomerular areas, mesangial areas and the number of mesangial cells of Doxorubicin nephropathy in rats were measured by quantitative morphometry study. Results: The mesangial areas and number of mesangial cells were significantly greater in the nephropathy group than those in the treated group and the control group (P<0.01), and there were some differences between the treated and the control group(P<0.05).Significant differences were also found on the ratio of mesangial area to glomerular capillary tuft area, the ratio of number of mesangial cells to glomerular capillary tuft area and the ratio of number of mesangial cells to mesangial area in the three groups.In Pearson’scorrelation analysis, the mesangial areas and the number of mesangial cells had positive correlation with the amount of proteinuria, the serum level of cholesterol and triglyceride in the fourth week (P<0.01), and had negative correlation with the serum albumin (P<0.01). Conclusion: Astragalus Membranaceus had therapeutical effects to Doxorubicin nephropathy through its influence on mesangium and mesangial cells.
出处
《医学研究生学报》
CAS
2005年第3期206-208,F002,共4页
Journal of Medical Postgraduates
关键词
黄芪
多柔比星肾病
病理学
图像分析
Astragalus membranaceus
Doxorubicin nephropathy
Pathology
Image analysis
