摘要
目的利用功能磁共振成像(fMRI)揭示针刺人体穴位所致大脑皮层神经生理兴奋的现象. 方法分别针刺'足阳明胃经'上的伏兔穴(S32,7例)、足三里穴(S36,9例)和'足少阳胆经'上的阳陵泉穴(G34,7例)、光明穴(G37,8例);其中男27例,女4例;年龄21～48岁,平均29.5岁; MR信号采集运用GE 1.5 T Signa Horizon LX 超导型MR仪;应用单次激发回波平面成像梯度回波序列(GRE-EPI),采集8层与解剖图像完全相同层面的功能图像,扫描参数为:TR 3000 ms,TE 40 ms,翻转角90°,视野24 cm×24 cm,层厚7 mm,间隔0.5 mm,矩阵64×64;图像数据在工作站(SUN,GE Advancd Workstation 3.1)上, 运用功能神经成像分析软件(analysis of functional neuroimage, AFNI)进行处理分析. 结果针刺伏兔穴和足三里穴可以引起下丘脑、海马回、额回的神经生理兴奋,平均血氧水平依赖(BOLD)信号强度增加(4.28±1.50)%;针刺光明穴和阳陵泉穴,同侧枕叶视皮层均有明显兴奋区,其中8例受试者(5例光明穴、3例阳陵泉穴)双侧枕叶视皮层都有明显兴奋区,针刺后枕叶视皮层兴奋的平均BOLD信号强度增加(3.3±1.2)%;此外,脑组织兴奋还见于额叶、颞叶、基底节和桥脑等.结论 fMRI可以显示针刺穴位后所致大脑相应区域的信号强度增加,由此提供了针刺某穴位可以引起大脑相应区域的神经生理兴奋的理论根据.
Objective To characterize the cortical activation of acupuncture with BOLD-based fMRI technique. Methods The study was performed in 31 healthy volunteers (27 men, 4 women; age range ~21- 48 years) with acupuncture of points along the stomach meridian of Foot-Yangming and the gallbladder meridian of Foot-Shaoyang. The acupoints of the stomach meridian of Foot-Yangming included Futu (S 32) in 7 volunteers and Zusanli (S 36) in 9 volunteers; and the acupoints of the gallbladder meridian of Foot-Shaoyang included Yanglingquan (G34) in 7 volunteers and Guangming (G37) in 8 volunteers. MRI data were acquired on a GE l.5 T Signa Horizon/Echo-speed scanner. 12 oblique axial slices paralleled to the AC-PC line were scanned. T_2* images were acquired using EPI technique. Data sets of sequential images were analyzed with software package AFNI. Results Acupuncture at points S32 and S36 resulted in activation of the hypothalamus, nucleus accumbens, hippocampal complex, and frontal gyri, and the average enhancement in the above activated areas was (4.28±l.50)%. Acupuncture at vision-related points G34 and G37 resulted in activation of the occipital lobe as well as other cortices such as pons, basal ganglion, temporal lobe, and frontal lobe, and the BOLD signal changes of the visual cortex were (3.31±l.2)%. Conclusion These preliminary fMRI results demonstrate strong regional BOLD signal changes in the brain upon acupuncture, hence demonstrates physiological evidence of acupuncture effect.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2005年第3期252-255,共4页
Chinese Journal of Radiology
基金
科技部"九五"攀登计划启动基金资助项目(国科基字:1998009010)
