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不同代次毒种乙脑减毒活疫苗的滴度和安全性实验结果比较 被引量:1

Comparison of titer and safety of live attenuated JEV vaccine prepared with virus strain at different passages
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摘要 为比较不同代次的乙脑毒种在疫苗制备过程中对疫苗质量的影响,特制备不同代次的工作种子SA14 14 2PHK7、PHK8、PHK9,检定合格后,分别用这几批毒种制备乙脑减毒活疫苗,检定和比较疫苗的滴度和各项安全性指标。实验表明SA14 -14 -2PHK7、PHK8和PHK9三个代次的乙脑毒种制备的乙脑疫苗平均滴度为 6. 43lgPFU/ml;乳鼠传代返祖试验均值为 1. 1lgLD50 /0. 03ml;致病力均为阴性。证实乙脑毒种SA14 -14 -2 10代以内的生物学特性是稳定的,对疫苗的影响无显著差异。10代以内的乙脑毒种可安全的用于疫苗生产。 To study the influence of JEV virus strain at different passages on the quality of JEV vaccine. JEV vaccines were prepared with virus strain SA14-14-2 PHK7, PHK8 and PHK9, which were 7~ th,8~ th,9~ th passages respectively. The titers and safety of these JEV vaccines were tested. The average titer of JEV vaccines prepared with SA14-14-2 PHK7, PHK8 and PHK9 was 6.43 lg PFU/ml. The test for neurovirulence reversion in infant mice was 1.1 lg LD 50/0.03ml, which was negative. The biological characters of JEV virus strain are stable within 10 passages which can be used for the vaccine production.
出处 《微生物学免疫学进展》 2005年第1期11-14,共4页 Progress In Microbiology and Immunology
关键词 冻干乙脑减毒活疫苗 毒种代次 滴度 安全性 JEV live attenuated vaccine Virus passages Titer Safety
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