组织多肽特异性抗原细胞角蛋白19和癌胚抗原联合检测在肺癌诊断中的临床意义被引量：9

Clinical Significance of The Tissue Polypeptide-specific Antigen(TPS),Cytokeratin 19 Fragment Marker (CYFRA21-1) and Carcinoembryonic Antigen (CEA) in The Diagnosis of Lung Cancer

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摘要目的 :评价组织多肽特异性抗原 (TPS)、CYFRA2 1- 1和癌胚抗原 (CEA)在各种病理类型肺癌中诊断的应用价值 ,通过联检观察它们在肺癌诊断中的敏感性和有效性。方法 :收集血清标本 12 7例 ,其中肺鳞癌 2 2例 ,腺癌 19例 ,小细胞肺癌 16例 ,不能分型肺癌组 13例 ,肺部良性疾病组 2 7例和正常对照 30例。采用酶联免疫吸附试验进行检测。结果 :TPS、CYFRA2 1- 1和CEA在肺癌各病理类型组的血清水平与正常对照组有差异 (P <0. 0 5 ) ,TPS和CEA在肺癌各病理类型组的血清水平高于良性病变组 (P <0 . 0 5 ) ,CYFRA2 1- 1在肺癌各病理类型组的血清含量与肺癌良性疾病组无差异 (P >0 . 0 5 )。TPS在肺癌组的灵敏度最高 ,为 85. 7% ,在肺部良性病变组的灵敏度为 2 9. 6 % ,TPS在肺癌各病理类型组的灵敏度无差异(P >0 .0 5 ) ,其特异性为 78 9%。CYFRA2 1- 1和CEA在肺癌的灵敏度分别为 2 7 .1%和 2 2 8% ,CYFRA2 1- 1在肺鳞癌中灵敏度最高 36 . 4 % ,CEA在肺腺癌中最高为 31 .6 %。TPS、NSE ,CYFRA2 1- 1和CEA三项联检 ,可明显提高肺癌诊断的灵敏度 ,但同时特异性有所下降。结论 :TPS在肺癌诊断上灵敏度较高 ,但特异性较差 ,不宜单独用于肺癌诊断。CYFRA2 1- 1和CEA在肺癌诊断上灵敏度较低 ,但特异性强 ,在肺癌诊? Objective:To evaluate the clinical value of TPS,CYFRA21-1 and CEA in the diagnosis of varied groups of lung cancer.To observe the sensitivity and accuracy by combined detection of three tumor markers.Methods:The serum samples of 127 patients were measured:including 22 squamous cell carcinomas,19 adenocarcinomas ,16 small-cell cancers,13 unclassified lung cancers,27 benign pulmonary diseases and 30 normal control groups.Serum was e dtected by ELISA.Results:There was a difference in serum level of TPS,CYFRA21-1 and CEA(P<0 05) between lung cancer groups and control groups.The serum level of TPS and SCLC is higher in lung cancer group(P<0 05) than that in benign group.There was no difference(P>0 05)in the serum level of CYFRA21-1between lung cancer groups and benign group.The sensitivity of TPS of 85.7% in lung cancer groups is the highest and it is 29.6% in benign groups and the specificity is 78.9%.There was no difference in sensitivity of TPS in varied lung cancer groups(P>0 05).The sensitivity of CYFRA21-1 and CEA is,respectively 27.1% and 22.8%.CYFRA21-1 shwed the highest sensitivity (36.4%) in squamous cell carcionmas,CEA highest in adenocarcinomas (31.6%).The combined detection of three tumor markers may improve the sensitivity for lung cancer detection,but specificity declines.Conclusion:Being the tumor markers with high specificity and sensitivity,TPS has a higher sensitivity in the detection of lung cancer but shows low specificity,thus can not be used alone in the detection of lung cancer.CYFR21-1 and CEA has a lower sensitivity but high specificity,thus shows some clinical value.The combined detection of three tumor markers can increase diagnosis rate of lung cancer,which shows some clinical value.

作者李文新博晓真张军力成绥生贾向东

机构地区内蒙古自治区医院肿瘤科内蒙古医学院免疫教研室内蒙古医学院附属医院检验科

出处《内蒙古医学杂志》 2005年第2期103-106,共4页 Inner Mongolia Medical Journal

关键词肺癌标志物 TPS CYFRA21—1 CEA 肺癌诊断 Tumor Markers TPS CYFRA21-1 CEA Lung cancer diagnosis

分类号 R446.62 [医药卫生—诊断学] R734.2 [医药卫生—肿瘤]

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